摘要
目的：观察局部晚期鼻咽癌TPF方案诱导化疗联合IMRT同期化疗的临床疗效和不良反应。方法回顾性分析2011年6月至2013年6月在本院就诊的54例接受诱导化疗联合IMRT同期顺铂化疗的中晚期鼻咽癌患者，按其所接受的诱导化疗方案，分为TPF组（24例）和PF组（30例）。分别于2程诱导化疗后第3周、放疗结束后3个月开始至一年，观察临床疗效和不良反应。结果 TPF组在诱导化疗后短期有效率（54.2%）较PF组（23.3%）有优势，P〈0.05，但在放化疗后有效率未见明显差异，且Ⅱ级以上中性粒细胞减少、和上消化道反应明显增加；两组1年生存率均为100％，无病生存率TPF组95.8％，PF组90.0％，P〉0.05。结论 TPF组在两程诱导化疗后短期有效率方面有优势，但其联合IMRT同期化疗的远期疗效有待于进一步研究。
Objective To investigate the clinical efficacy and adverse events with intensity-modulated radiotherapy （IMRT） and concurrent chemotherapy following TPF induction chemotherapy in locally advanced nasopharyngeal carcinoma. Methods A retrospective analysis was conducted of 54 patients with advanced nasopharyngeal carcinoma（NPC）in our hospital who received IMRT and concurrent cisplatin-based chemotherapy following an induction regimen between June 2011 and June 2013. According to the induction chemotherapy they received,the subjects were divided into TPF group（n=24）and PF group （n=30）. The clinical efficacy and adverse events in these patients were evaluated at 3 weeks after the two-cycle induction chemotherapy,and at every 3 months until one year after radiotherapy. Results The TPF group showed a short-term rate of effectiveness after induction chemotherapy which seemed advantageous over the rate in PF group（54.2%vs 23.3%,P〈0.05）. However,the TPF induction did not lead to significant difference in efficiency after chemoradiotherapy,and was more likely to result in neutropenia（gradesⅡor higher）and upper gastrointestinal reactions. The 1-year survival rate was 100%in two groups;the disease-free survival was 95.8%in the TPF group vs 90.0%in the PF group（P〉0.05）. Conclusion TPF regimen used for two-cycle induction chemotherapy may be advantageous in short-term clinical efficacy,but needs further study with regards to its long-term efficacy in IMRT and concurrent chemotherapy.
出处
《中华生物医学工程杂志》
CAS
2016年第1期50-53,共4页
Chinese Journal of Biomedical Engineering
