摘要
目的对中药单体化合物莪术醇进行处方前研究,为制剂研究奠定基础。方法建立莪术醇液相分析方法,对莪术醇平衡溶解度、油水分配系数、稳定性进行研究。结果莪术醇在纯水中平衡溶解度在25℃下为1.93 mg/ml,在37℃下为2.6 mg/ml。莪术醇的Log P为2.2~3.0。在高温和光照条件下,莪术醇均不稳定。p H对莪术醇溶液稳定性影响较小。结论建立的分析方法准确可靠。莪术醇微溶于水,亲脂性强,可通过增溶技术或制成纳米制剂来提高其生物利用度。莪术醇应阴凉处保存,避光操作。
Objective To study the physical-chemical parameters of curcumenol so as to design its optimal preparations.Methods An HPLC method was established to determine the content of curcumenol. Based on the method,the equilibrium solubility,oil/water partition coefficient and stability of curcumenol were investigated. Results The equilibrium solubility in the pure water was1.93 mg/ml（25 ℃）and 2.6 mg/ml（37℃）,respectively. The oil/water partition coefficient was in the range of 2.2-3.0. Curcumenol solution was unstable at high temperature under light conditions,while p H value showed little effect. Conclusion The analytical method is accurate and reliable. The solubility of curcumenol can be described as strong lipotropic and slightly soluble in water. Nanoformulation and solubilization technologies could improve its bioavailability significantly. Curcumenol should be stored and operated in a dark and cool place.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2016年第3期562-565,共4页
Journal of International Pharmaceutical Research
关键词
莪术醇
平衡溶解度
油水分配系数
稳定性
curcumenol
solubility
oil-water partition coefficient
stability
