摘要
目的 探讨分析利巴韦林气雾剂治疗患儿手足口病的临床效果及病毒阴转率情况.方法 选取本院儿科2015年1月至8月收治的轻症手足口病患儿89例,采取随机数字的方法分成对照组（44例）和观察组（45例）.两组均营养支持、静脉滴注抗病毒药物治疗,同时观察组给予利巴韦林气雾剂治疗,对照组给予安慰剂作为阴性对照.治疗1周后,对比两组治疗前后临床效果及病毒转阴率情况.结果 经过1周治疗,观察组发热、鼻塞、咳嗽、口腔溃疡、皮疹等症状缓解率明显高于对照组,差异具有统计学意义（P＜0.05）.两组治疗前咽拭子检测病毒阳性率差异无统计学意义（P＞0.05）;治疗后,观察组病毒阴转率明显高于对照组,差异具有统计学意义（P＜0.05）.结论 在轻症手足口病治疗时,给予患儿对症补液处理的同时加用利巴韦林气雾剂能够明显提高临床效果,提高病毒阴转率,值得临床推广使用.
Objective To investigate and analyze the clinical effect ofribavirin aerosol in the treatment of children with hand,foot,and mouth disease （HFMD） and the virus negative rate.Methods 89 children with mild HFMD treated at the department of pediatrics at our hospital from January to August,2015 were selected and were randomly divided into a control group （n=44） and an observation group （n=45）.Both groups were given nutritional support and intravenously dripped antiviral drugs;in addition,the observation group were treated with ribavirin aerosol and the control group were given placebo.After 1 week＆#39;s treatment,the clinical effects and viral negative rates were compared between these two groups before and after the treatment.Results After one week＆#39;s treatment,the total effective rate was obviously higher in the observation group than in the control group,with a statistical difference （P〈0.05）.There was no statistical difference in virus positive rate between these two groups before the treatment （P〉0.05）.After the treatment,the virus negative rate was significantly higher in the observation group than in the control group,with a statistical difference （P〈0.05）.Conclusions Symptomatic rehydration therapy combined with ribavirin aerosol for mild HFMD is significantly effective and can increase virus negative rate,so it is worth being clinically generalized.
出处
《国际医药卫生导报》
2016年第14期2125-2127,共3页
International Medicine and Health Guidance News
关键词
利巴韦林气雾剂
手足口病
临床疗效
病毒阴转率
Ribavirin aerosol
Hand,foot,and mouth disease
Clinical efficacy
Virus negative rate
Ribavirin aerosol
Hand,foot,and mouth disease
Clinical efficacy
Virus negative rate
