摘要
目的:评价在手足口病的治疗中共同使用蓝芩口服液和利巴韦林气雾剂的临床作用。方法:选取2014年8月—2015年6月在医院接受诊断和治疗88例手足口病患者,按照随机数字表法分为两组,对照组给予单一利巴韦林气雾剂治疗,实验组给予蓝芩口服液联合利巴韦林气雾剂治疗。对比两组患者临床症状好转时间、病毒转阴情况、临床综合作用效果和不良反应发生情况。结果:实验组患者的退热、疱疹结痂、疱疹消退、初次进食时间与对照组患者的相比明显缩短;实验组患者的EV71病毒的转阴率(92.31%)、总肠道病毒转阴率(92.68%)明显高于对照组患者的EV71病毒的转阴率(61.54%)、总肠道病毒转阴率(65.85%);实验组患者总有效率(90.91%)与对照组的(70.45%)存在明显差异,差异均有统计学意义(P<0.05)。实验组患者不良反应发生率6.82%与对照组的9.09%相比,差异无统计学意义(P>0.05)。结论:蓝芩口服液联合利巴韦林气雾剂治疗手足口病临床效果显著,加快患者临床症状改善的程度,提高临床病毒的转阴率。
Objective： To evaluate the clinical effect of ribavirin aerosol suspension combined with Lanqin Oral Liquid in the treatment of hand-foot-mouth disease（ HFMD）.Methods： From August 2014 to June 2015 in our hospital,88 cases of children with hand-foot-mouth disease were divided into 2 groups according to the random number table.Patients of the control group were given ribavirin aerosol suspension treatment and patients of the experimental group were given ribavirin aerosol suspension combined with Lanqin Oral Liquid treatment.Clinical symptoms improved time,the virus negative rate,clinical effect and adverse reactions of two groups were compared.Results： The experimental group＇fever,herpes scab,bleb subsidise,first time to eat were significantly shorter than those of the control group and the experimental group＇s EV71 virus seroconversion rate（ 92.31%） and total intestinal virus clearance rate（ 92.68%） were significantly higher than the control group ＇s EV71 virus negative rate（ 61.54%） and total intestinal virus clearance rate（ 65.85%）.The total efficiency rate of the experimental group（ 90.91%） compared with the control group＇s（ 70.45%）had statistically significant difference（ P〈0.05）.The incidence of adverse reaction in the experimental group（ 9.09%）compared with the control group＇s（ 6.82%） had statistically significant difference（ P〈0.05）.Conclusion： Lanqin Oral Liquid combined with ribavirin aerosol suspension in the treatment of hand-foot-mouth disease has significant clinical effect,accelerating the improvement of clinical symptoms and improving the clinical virus seroconversion rate.
出处
《中华中医药学刊》
CAS
北大核心
2016年第4期867-869,共3页
Chinese Archives of Traditional Chinese Medicine
基金
河北省卫生厅科研项目(20110168)
