摘要
目的:建立革除汞盐的氢氧化钠电位滴定法测定盐酸米多君原料药的含量。方法:采用Mettler Toledo DG111-SC(pH 0-14,0-70℃)复合电极,以乙醇为溶剂,采用氢氧化钠滴定液(0.1mol·L^(-1))滴定,并与国家药品试行标准YBH09272004中含量测定原方法进行了比较。结果:空白无干扰,重复性良好,成功革除醋酸汞,两种测定方法含量结果比较无明显差异。结论:建立的新方法革除了醋酸汞,滴定突跃明显,方法简单易行,重复性好。
Objective： To establish a mercury-free sodium hydroxide potentiometric titration method for the assay of midodrine hydrochloride. Methods： Mettler DG111 （Ph 0-14,0-70℃ ） was used as the composite electrode, the ethanol was used as the sol- vent and sodium hydroxide （0.1 tool·L-1 ） was used as titrating solution. The method was compared with the original methods stated in YBH09272004. Results： The experiments had better repeatability and the blank had no interference. The result showed that there was no significant difference between two kinds of methods. Conclusion： The improved method discards mercuric salt and obtain an abrupt change of the titration cruve. It is simple, reproducible and accurate for the determination of midodrine hydrochloride.
出处
《四川生理科学杂志》
2016年第2期59-61,共3页
Sichuan Journal of Physiological Sciences
关键词
盐酸米多君
含量
测定方法
革除汞盐
Midodrine Hydrochloride
Assay
Method
Discard mercurate
