摘要
抗菌肽的发现与研究已有几十年的历史,抗菌肽是一类生物体中普遍存在并具有广谱抗微生物活性的小分子多肽,被科学家誉为"天然抗生素"。海洋动物抗菌肽是鱼、虾、蟹、贝等海洋动物的非特异性免疫防御系统的重要组成部分,在海洋环境中对于防御外源病原菌的入侵起到重要作用。海洋抗菌肽的研发与应用,不仅具有重要的医学开发价值,也是减少抗生素污染、实现海水健康养殖的重要保障。本文主要以鱼类抗菌肽和甲壳类抗菌肽为例,从抗菌肽的来源与分类、结构特点以及生物学活性等方面,简要概述近年来海洋鱼类和甲壳类抗菌肽的一些研究进展及其开发利用前景。
Antimicrobial peptides are a group of small peptides with broad - spectrum antimicrobial activities, which have been studied for several decades. Antimicrobial peptides are thought to be ＂ natural antibiotics＂ . Marine antimicrobial peptides are considered to be one of the important components of innate immune defense system in fish, shrimp, crab, shellfish and other marine animals. Marine antimicrobial peptides play an important role in the defense of exogenous pathogens in the marine environment. The development and application of marine antimicrobial peptides not only has an important prospect of medical development, but also is an important safeguard to reduce antibiotic contamination and achieve the healthy breeding of marine animals. Here we make a brief introduction of the research and application prospects of antimicrobial peptides from marine fish and crustacean, and the source and classification of antimicrobial peptides, structural characteristics and biological activity will be clarified.
出处
《渔业研究》
2016年第3期254-262,共9页
Journal of Fisheries Research
基金
福建省高校产学合作科技重大项目计划(2013N5010)
福建省产业创新技术重大研发平台项目(2014N2004)
厦门南方海洋研究中心项目(13GZP001NF06)
关键词
海洋动物
抗菌肽
鱼类
甲壳动物
应用前景
marine animals
antimicrobial peptides
fish
crustacean
application prospect
