摘要
目的比较黄芩药材及其配方颗粒中黄芩苷的含量差异,为配方颗粒生产工艺的改进提供理论依据。方法采用高效液相色谱-梯度洗脱法,对黄芩药材及其配方颗粒中黄芩苷的含量进行测定,比较两者含量的差异。结果配方颗粒中黄芩苷的含量是原黄芩药材含量的1/5,与所标示的浓缩倍数不符。结论原配方颗粒的生产工艺需要改进;配方颗粒需要建立完善的质量控制方法和合理的质量标准。
OBJECTIVE To compare the content of Baicalin between scutellalria baicalensis georgi and it＇s dispensing granule,and to provide theoretical basis for dispensing granule to improve the production process of particles. METHODS HPLC was used to determine the content of Baicalin between scutellalria baicalensis georgi and it＇s dispensing granule,and compared the difference between the two contents. RESULTS The content of Baicalin in dispensing granule were one fifth of the original scutellalria baicalensis georgi,and the daily amounts of the major components in the commercial Lianqiao granule were not equivalent in the decoction of scutellalria baicalensis georgi. CONCLUSION So the original dispensing granule production process needs to be improved,the standardized criteria for the quality control of dispensing granule should be established and the manufacturing process,the criteria for raw material selection should be assessed and improved.
出处
《海峡药学》
2016年第5期49-51,共3页
Strait Pharmaceutical Journal
关键词
黄芩药材
配方颗粒
黄芩苷
含量测定
Scutellalria baicalensis georgi
Dispensing granule
Baicalin
Quantitative determination
