摘要
目的观察苯那普利对糖尿病大鼠心功能的保护作用。方法大鼠腹腔注射链脲佐菌素(STZ)诱导糖尿病模型,并随机分成糖尿病组和苯那普利组,未予注射STZ的大鼠为对照组。苯那普利组予苯那普利药粉自来水溶解后灌胃,对照组和糖尿病组予自来水灌胃。8周后予心脏超声测左心室舒张末期内径(LVIDD)、左心室收缩末期内径(LVIDS)、射血分数(EF)、左心室短轴缩短率(FS)、血流动力学检查测左心室峰压(LVSP)、左心室舒张末压(LVEDP)、左心室内压最大上升(+dp/dt)和下降速率(-dp/dt),并测心脏重量指数。结果心脏超声显示:与对照组相比,糖尿病组LVIDD、FS、EF显著减少;与糖尿病组相比,苯那普利组LVIDS明显减少,EF、FS显著增加。血流动力学测定与对照组相比,糖尿病组+dp/dt显著下降,LVSP、LVEDP、-dp/dt差异无统计学意义(P>0.05);与糖尿病组相比,苯那普利组+dp/dt显著增加,LVSP、LVEDP、-dp/dt差异无统计学意义。与对照组相比,糖尿病组心脏重量指数显著增加;与糖尿病组相比,苯那普利组心脏重量指数差异无统计学意义(P>0.05)。结论 STZ诱导的糖尿病大鼠8周时发现心功能不全,苯那普利对糖尿病大鼠的心功能具有保护作用。
Objective To examine the protective effect of Benazepril on cardiac function in diabetic rats.Methods Diabetic model was induced in rats by intraperitoneal injection of streptozotocin（STZ）.The successful model of diabetic rats were randomly divided into diabetic group and benazepril group.The control group were rats that were not injected with STZ.Ratsin the control group and diabetic group were fed with tap water by gavage and the benazepril group with benazepril powder dissolved tap water.After 8 weeks,cardiac ultrasound was used to measure left ventricular end diastolic diameter （LVIDD）,left ventricular end systolic diameter （LVIDS）,ejection fraction （EF）,left ventricular fraction shortening （FS）.And left ventricular peak pressure （LVSP）,left ventricular end diastolic pressure （LVEDP）,maximal rates of pressure development and decline were measured by ventricular intubation.And heart weight index was also measured.Results Echocardiography showed：that in the diabetic group compared with the control group,LVIDD,FS,EF were significantly decreased.Compared with the diabetes Group,LVIDS of benazepril group was significantly decreased,EF,FS were significantly increased.Hemodynamics showed：in the diabetic group,compared with the control group,＋ dp / dt was decreased significantly.And LVSP,LVEDP,-dp/dt showed no significant differences.Compared with diabetes group,＋ dp / dt of benazepril group increased significantly.But LVSP,LVEDP,-dp/dt showed no significant differences.Compared with the control group,the heart weight index significantly increased.Compared with diabetic group,the heart weight index of benazepril group showed no significant differences.Conclusion Cardiac insufficiency was found in STZ-induced diabetic rats at eighth week.Benazepril showed a protective effect in the cardiac function of diabetic rats.
出处
《医学研究杂志》
2016年第6期146-149,共4页
Journal of Medical Research
关键词
苯那普利
糖尿病
大鼠
心功能
Benazepril
Diabetes mellitus
Rat
Cardiac function
