摘要
目的探讨高分辨螺旋CT评估中度哮喘患儿哮喘病情以及预后的临床价值。方法选取自2013年4月-2015年5月我院收治的40例中度哮喘患儿作为本次研究的观察组,另选取同期我院收治的患有其他系统疾病的患儿40例,作为对照组。测试两组患者的肺功能,并对患者进行高分辨螺旋CT扫描,测量并计算气道壁厚度。比较两组患者的各项肺功能指标、气道壁厚度及面积的相关测量值和计算值,同时分析气道壁厚度与肺功能的相关性。结果观察组患者FEV1、FEV1/FVC、PEF、FEF25-75、RV/TLC等肺功能指标的测量值分别为(69.1±4.1)%、(65.4±7.8)%、(74.2±10.5)%、(44.3±16.7)%、(32.5±6.3)%,均明显小于对照组(P<0.05)。HRCT扫描后,观察组患者的气腔外径(D)、气道壁厚度(T)、T/D值、气道总横截面积(Ao)、气道壁面积(WA)、支气道横截面积百分比(WA%)分别为(4.78±0.89)mm、(1.30±0.43)mm、(28.6±5.2)%、(20.13±6.85)mm、(15.14±5.89)mm、(74.85±7.23)%,均明显大于对照组(P<0.05)。WA%与肺功能指标FEV1呈负相关(r=-0.611,P=0.01),T/D、WA%其他肺功能指标、年龄、病程无相关性(P>0.05)。结论 HRCT扫描能够准确、有效的测量出哮喘患儿的支气管壁厚度,评估患者的气道重构,可用于哮喘病情及预后的评估。
Objective To investigate the high resolution spiral CT moderate asthma in children with asthma and clinical prognostic value. Methods Children 40 cases since April 2013-May 2015 40 cases of moderate asthmatic children in our hospital, as observed in this study group, select another year in our hospital suffering from other diseases, as in the control group. Both groups were tested lung function, and in patients with highresolution spiral CT scan, measure and calculate the airway wall thickness. The two groups were compared lung function, airway wall thickness and size of the associated measurement and calculated values, and analyzes of airway wall thickness correlated with lung function. Results The patients in the observation group measured FEV1, FEV1 / FVC, PEF, FEF25-75, RV/TLC and other lung function parameters were（69.1±4.1）%,（65.4±7.8）%,（74.2±10.5）%,（44.3±16.7）%,（32.5±6.3）%,Significantly less than the control group（P〈0.05）. After HRCT scans of patients in the observation group gas chamber outer diameter（D）, airway wall thickness（T）, T/D value, total airway crosssectional area（Ao）, airway wall area（WA）, bronchial tract percentage cross-sectional area（WA%） were（4.78±0.89） mm,（1.30±0.43） mm,（28.6±5.2）%,（20.13±6.85） mm,（15.14±5.89） mm,（74.85±7.23） %, significantly higher than the control group（P〈0.05）. WA% was negatively correlated with lung function parameters FEV1（r=-0.611, P=0.01）, T/D, WA% other lung function parameters, age, duration no correlation（P〈0.05）. Conclusion HRCT scan can accurately and effectively measure the wall thickness of bronchial asthma in children, to assess the patient＇s airway remodeling, asthma and can be used to assess prognosis.
出处
《中国CT和MRI杂志》
2016年第7期64-67,共4页
Chinese Journal of CT and MRI
关键词
高分辨螺旋CT
中度哮喘
气管壁厚度
肺功能
High Resolution Spiral CT
Moderate Asthma
Airway wall Thickness
Lung Function
