摘要
目的 :探讨江苏省部分地区HIV阳性的男男性行为者(men who have sex with men,MSM)抗病毒治疗耐药发生情况及其影响因素。方法:采用前瞻性动态队列研究,纳入符合标准的治疗者随访观察,计算基因型耐药发病密度,用COX回归模型探讨发生耐药的影响因素。结果:本研究共纳入符合标准的MSM 407例,总观察人时为845.77人年,随访期间共有23例发生基因型耐药,发病密度为2.72/100人年。多因素COX回归分析显示治疗前CD4+T淋巴细胞计数≤200个/μL、治疗起始用药方案是发生基因型耐药的危险因素。结论:江苏省参加抗病毒治疗的MSM耐药率处在较低水平,建议对该人群实行早治疗策略,治疗起始方案推荐优先选用含依非韦伦(EFV)的方案。
Objective：To investigate the incidence and correlates of HIV-1 drug resistance among men who have sex with men（MSM）on highly active antiretroviral therapy（HAART）. Methods：We conducted a prospective cohort study in Jiangsu province to estimate the incidence of HIV-1 drug resistance（HDR）. Cox regression model was used to investigate the correlations of HDR.Results：During the follow-up period,23 MSM acquired drug resistance,and the incidence was 2.72 per 100 person-years. The independent risk factors of HDR were the CD4＋T cell count（less than 200 copies / μl）before ART（HR：3.210;95%CI：1.333~7.733）,and the use of nevirapine（NVP）on initial regimen（HR：2.852;95% CI：1.194 ~6.817）. Conclusion：The incidence of HDR among MSM on ART was low. Early treatment of MSM infected with HIV-1 was recommended according to our study. It’s better to use EFV rather than NVP when initiate ART.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2016年第5期636-640,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省医学重点人才(RC2011087
RC2011086)
江苏省艾滋病抗病毒治疗病人HIV-1病毒耐药性的队列研究(Y2012069)
