摘要
目的:了解临沂市人民医院(以下简称"我院")药品不良反应(adverse drug reaction,ADR)的发生情况及其特点,为临床合理用药提供参考。方法:对我院2011年1月—2013年6月上报至国家ADR监测中心的909例ADR报告进行回顾性统计分析。结果:909例ADR报告中,男性与女性的比例为1.04∶1;606例(占66.67%)由静脉途径给药引起;336例(占36.96%)由感染性疾病用药引起[其中296例(占88.10%)由抗菌药物引起];ADR累及器官和(或)系统以皮肤及其附件最多;严重的ADR有52例[其中18例(占34.62%)由抗菌药物引起]。结论:感染性疾病用药,特别是抗菌药物的使用是ADR发生的常见诱因,临床主要表现为各种皮疹和瘙痒,临床应合理应用抗菌药物,以避免和减少ADR的发生。
OBJECTIVE： To investigate the incidence and characteristics of adverse drug reaction（ ADR） in Linyi Pharmaceutical Industrial School（ hereinafter referred to as ＂our hospital＂）,so as to provide reference for the rational drug use in clinic. METHODS： 909 cases of adverse drug reaction reports reported to National Monitor Center of ADR from Jan. 2011 to Jun. 2013 were statistically analyzed. RESULTS： Of the 909 cases of ADR reports,the ratio of male to female was 1. 04∶ 1. 606 cases（ 66. 67%） were induced by the intravenous route of administration; 336 cases（ 36. 96%） were induced by the infection medication,of which 296 cases（ 88. 10%） were induced by antibiotics; skin and its accessories damage accounted for the highest percentage of ADR. 52 cases were severe adverse reactions,of which 18 cases（ 34. 62%） were induced by antibiotics. CONCLUSIONS： Drugs for infectious diseases,especially antibiotics was a common cause of ADR,the main clinical manifestations were skin rash and pruritus. Rational use of antibiotics should be emphasized in the clinical practice in order to prevent and reduce the occurrence of ADR.
出处
《中国医院用药评价与分析》
2016年第5期673-676,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
