摘要
目的:探讨比索洛尔与辛伐他汀联合治疗老年不稳定型心绞痛的疗效。方法:选取南华大学附属第一医院2012年9月—2014年9月收治的80例老年不稳定型心绞痛患者,按随机数字表法分为2组各40例。对照组患者给予辛伐他汀治疗,观察组患者在对照组治疗基础上联合比索洛尔治疗。8周为1个疗程,比较2组患者的临床疗效、心电图异常改善程度及不良反应发生情况。结果:临床症状改善方面,观察组患者总有效率为87.5%(35/40),对照组为65.0%(26/40),差异有统计学意义(P<0.05);心电图异常改善方面,观察组患者总有效率为72.5%(29/40),对照组为42.5%(17/40),差异有统计学意义(P<0.05);观察组患者不良反应发生率为35.0%(14/40),对照组为22.5%(9/40),差异无统计学意义(P>0.05)。结论:比索洛尔与辛伐他汀联合治疗老年不稳定型心绞痛,疗效显著,可明显降低患者心绞痛发作次数,改善心电图异常表现,且安全性高,值得推广。
OBJECTIVE： To probe into the efficacy of bisoprolol combined with simvastatin in treatment of elderly patients with unstable angina pectoris. METHODS： 80 patients with unstable angina pectoris admitted into the First Affiliated Hospital of Nanhua University from Sept. 2012 to Sept. 2014 were selected to be divided into two groups via the random number table,with 40 cases in each. The control group were treated with simvastatin,while the observation group additionally received bisoprolol based on the control group; 8 weeks for a treatment course. After treatment,the clinical efficacy,improvement of electrocardiogram abnormality of the patients and incidence of adverse drug reactions were compared between two group of patients. RESULTS： The total effective rate of observation group was 87. 5%（ 35 /40）,and control group was 65. 0%（ 26 /40）,the difference was statistically significant（P〈0. 05）.As for the improvement of electrocardiogram（ ECG） abnormality： the total effective rate of observation group was72. 5%（ 29 /40）,and control group was 42. 5%（ 17 /40）,with statistical significance（P〈0. 05）. The incidence of adverse drug reactions in observation group was 35. 0%（ 14 /40）,and in control group was 22. 5%（ 9 /40）,with no statistical significance（P〈0. 05）. CONCLUSIONS： The efficacy of bisoprolol combined with simvastatin in treatment of elderly patients with unstable angina pectoris is remarkable,which can significantly reduce the frequency of angina attack in patients,improve the patient＇s ECG abnormalities with high safety. It is worthy of promotion.
出处
《中国医院用药评价与分析》
2016年第5期610-612,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
不稳定型心绞痛
心电图异常
比索洛尔
辛伐他汀
Unstable angina pectoris
Electrocardiogram abnormality
Bisoprolol
Simvastatin
