摘要
目的 分析比索洛尔联合辛伐他汀治疗老年不稳定心绞痛的临床效果。方法 从2017年9月至2018年9月到我院进行治疗的不稳定性心绞痛患者中选择78例患者作为研究对象,均按照随机方法分为观察组和对照组,每组平均为39例。两组患者均常规用药辛伐他汀,观察组在对照组用药基础上联合用药比索洛尔。对两组患者经过不同治疗之后的治疗有效率、治疗前后的LVEDD、LVEF指标、心绞痛发作次数和发作时间、用药不良反应发生率、用药前后的疼痛、负面情绪、用药前后的生活质量等进行统计,并对所有数据进行统计学分析和比较。结果 (1)观察组(35例,占89.74%)经两种药物联合治疗后的总有效率相对于对照组(28例,占71.79%)单药治疗而言更高(P<0.05)。(2)治疗以前,观察组和对照组在LVEDD、LVEF指标、心电图ST段、心绞痛发作次数和心绞痛发作时间方面的差异无显著性(P>0.05),治疗后,两组患者的LVEDD、LVEF指标、心电图ST段、心绞痛发作次数和心绞痛发作时间都得到了改善,但观察组的改善效果更突出(P<0.05)。(3)治疗以前两组患者的疼痛较重,负面情绪较严重,且两组比较无差异(P>0.05),治疗后两组患者的疼痛程度和和负面情绪均得到改善,但观察组改善更突出(P<0.05)。(4)观察组(5例,占12.82%)经过联合用药治疗后出现的不良反应发生概率和对照组(4例,占10.26%)单药治疗相比,差异不显著(P>0.05)。(5)治疗前两组患者生活质量较差且组间的差异不显著(P>0.05),治疗后,患者的生活质量都有所改进,但观察组患者的生活质量改善更为突出(P<0.05)。结论 通过比索洛尔和辛伐他汀两种药物联合用药对老年不稳定性心绞痛患者进行治疗所取得的效果明显优于单纯用药先伐他汀,不仅不会产生严重的用药不良反应,而且能提高患者的治疗,总有效率。实现对患者心功能指标的调节,可以减轻心绞痛�
Objective To analyze the clinical efiect of bisoprolol combined with simvastatin in the treatment of senile unstable angina pectoris.Methods Seventy-eight patients with unstable angina pectoris who were treated in our hospital from September 2017 to September 2018 were selected as the research subjects, and they were randomly divided into observation group and control group, with an average of 39 cases in each group. Both groups of patients were routinely treated with simvastatin, and the observation group was treated with bisoprolol on the basis of the control group. After difierent treatments, the efiective rate of treatment, LVEDD and LVEF indexes before and after treatment, the number and time of angina pectoris attacks, the incidence of adverse drug reactions, the pain before and after treatment, negative emotions, and the quality of life before and after treatment were analyzed., and perform statistical analysis and comparison of all data. Results(1) The total efiective rate of the observation group(35 cases, accounting for 89.74%) after the combined treatment of the two drugs was higher than that of the control group(28 cases, accounting for 71.79%) single drug treatment(P<0.05).(2) Before treatment, there was no significant difierence between the observation group and the control group in LVEDD, LVEF index, ECG ST segment, the number of angina pectoris attacks and the time of angina pectoris attack(P>0.05), LVEDD, LVEF indexes, ECG ST segment, angina attack times and angina attack time were improved in both groups, but the improvement efiect in the observation group was more prominent(P<0.05).(3) Before treatment, the pain and negative emotions of the patients in the two groups were heavier, and there was no significant difierence between them(P>0.05). After the treatment, the pain and negative emotions of the two groups were improved, however, the improvement in the observation group was more prominent(P<0.05).(4) The incidence of adverse reactions in the observation group(5 cases, accounting for 12.82%)
作者
李晓媛
LI Xiaoyuan(Liaoyang Second People's Hospital,Liaoyang 111000,China)
出处
《中国医药指南》
2022年第9期65-68,共4页
Guide of China Medicine
