摘要
背景与目的:三阴性乳腺癌(triple-negative breast cancer,TNBC)是目前乳腺癌研究关注的焦点。有研究显示,不同民族其分子生物学特征也不尽相同。该研究旨在分析汉族及维吾尔族女性TNBC患者表皮生长因子受体(epidermal growth factor receptor,EGFR)、血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达情况,了解其与预后间的关系。方法:选择新疆医科大学附属肿瘤医院2007年1月—2009年1月收治的汉族、维吾尔族女性TNBC患者167例,其中汉族患者121例,维吾尔族患者46例,应用PV-9000免疫组织化学染色方法测定其EGFR、VEGF的表达状态,并与淋巴结转移情况及临床分期进行比较,结果采用用SPSS 18.0统计软件进行分析。结果:汉族与维吾尔族女性患者在5年无病生存期方面差异无统计学意义(P>0.05);同时汉族患者EGFR、VEGF阳性率低于维吾尔族患者(P<0.05),并且其表达均与TNM分期及淋巴结转移呈正相关(0<r<1,P<0.05)。结论:汉族女性TNBC患者EGFR、VEGF的阳性率低于维吾尔族女性患者,但两组5年无病生存期差异无统计学意义(P>0.05),提示维吾尔族TNBC患者可能存在与汉族患者不同的影响其预后的因素,需开展进一步研究证实。
Background and purpose： Triple-negative breast cancer （TNBC） is currently the focus of breast cancer research. Researches demonstrated that the molecular biological characteristics of different ethnic groups are not the same. This study mainly probed into the expression of endothelial growth factor receptor （EGFR） and vascular endothelial growth factor （VEGF） in Han and Uygur TNBC patients, and the relationship between the expression and prognosis of patients. Methods： From Jan. 2007 to Jan. 2009, 167 patients were admitted. Among those, 121 were Han and 46 were Uygur patients. The expressions of EGFR, and VEGF were detected by PV-9000 immunohistochemical staining, and compared with lymph node metastasis and clinical staging. The results were analyzed by SPSS 18.0 statistical software. Results： Five-year disease-free survival （DFS） of two groups had no indifferent （P〉0.05）. EGFR and VEGF positive rate of Han patients was lower than that of Uygur patients （P〈0.05）. Their expressions were correlated with TNM staging and lymph node metastasis （0〈r〈l,P〈0.05）, Conclusion： This study found that the EGFR and VEGF expression rate which was unfavorable to prognosis of TNBC patients was lower in the Uygur group than that in the Han group. However, no significant difference in 5-year DFS was found between the two groups （P〉0.05）. Uygur TNBC patients might have a different prognostic factor as compared with Hart patients. Further studies need to be carried out.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2016年第5期404-408,共5页
China Oncology
基金
国家自然科学基金(81260390)
新疆维吾尔自治区科技厅科技支疆项目(2013911116)
关键词
表皮生长因子受体
血管内皮生长因子
汉族
维吾尔族
三阴性乳腺癌
Endothelial growth factor receptor
Vascular endothelial growth factor
Han
Uygur
Triple-negative breast cancer
