摘要
目的探讨宫颈小细胞癌(small cell carcinoma of cervix,SCCC)的临床病理特点,分析治疗效果及预后。方法回顾性分析2009年1月至2015年3月武汉大学人民医院收治的原发性SCCC患者的临床及病理资料,分析治疗方法的选择及预后。结果 13例SCCC占我院同期收治的所有宫颈癌的0.6%。根据国际妇产科联合会2014标准进行分期:ⅠB1期2例,ⅠB2期5例,ⅡA1期2例,ⅡA2期3例,ⅣA期1例。将13例患者根据临床分期的不同分别行新辅助化疗、根治术、术后化疗、同步放化疗等综合治疗。截止2015年3月,平均随访时间为38.6个月,患者中4例死亡,9例无瘤生存。结论 SCCC发病罕见,主要以病理学诊断为主,结合免疫组化染色提高准确率。临床分期Ⅰ期者预后较好,Ⅱ期及以上者进展迅速,恶性程度高,容易发生远处转移。故应对患者进行早期诊断及选择个性化的治疗方式,改善预后提高生存率。
Objective To explore the clinicopathologic characteristics of small cell carcinoma of the cervix（SCCC） and analyze the therapeutic effects and prognosis. Methods The clinical and pathological data which diagnosed as SCCC in People＇ s Hospital of Wuhan University from January 2009 to March 2015 were collected and followed up. To analyze the treatment method and prognosis of SCCC. Results The incidence of 13 cases of SCCC accounts for about 0.6 % in all cervical cancer during the same period in our hospital. 13 cases of SCCC were staged according to the standard of and obsterics（ international federation of gyncology and obstetrics, FIGO） 2014： I bl stage 2 cases, I b2 stage 5 cases, Ⅱ al stage 2 cases, Ⅱ a2 stage 3 cases, Ⅳa stage 1 case. Comprehensive treatment including neoadjuvant chemotherapy, radical operation, postoperative chemotherapy, concurrent radiochemotherapy were adopted respectively for 13 patients according to different clinical stages. The average follow - up time was 38.6 months. By March 2015, 4 cases died, 9 cases of disease -free survival. Conclusion SCCC is a rare tumour, and the diagnosis mainly depends on pathological examination which combining with immunohistochemical staining to improve diagnostic accuracy. The prognosis of stage I is well, however phase II and above which has high malignant degree and prone to distant metastases progresses rapidly. So early diagnosis and personalized treatment method can improve the survival rate.
出处
《中国计划生育和妇产科》
2016年第6期46-50,55,共6页
Chinese Journal of Family Planning & Gynecotokology
关键词
宫颈小细胞癌
病理特点
治疗
预后
SCCC
pathological characteristics
treatment
prognosis
