摘要
目的探讨JAK2V617F基因突变阳性骨髓增殖性肿瘤(MPN)患者常规凝血功能的改变及伴发血管性疾病的关系。方法收集2008年4月至2015年4月共68例MPN患者的临床资料和实验室检测结果,其中伴发血管性疾病28例,无血管性疾病40例。回顾性分析JAK2V617F基因突变与各项指标及血管性疾病间的关系。结果(1)68例MPN患者中存在JAK2V617F基因突变45例(66%),其中27例(79%)真性红细胞增多症(PV),16例(53%)原发性血小板增多症(ET),2例(50%)原发性骨髓纤维化(PMF)。(2)MPN患者与正常健康对照组比较,血细胞计数及常规凝血指标差异有统计学意义(P<0.05或<0.01)。其中JAK2V617F基因突变阳性患者与JAK2V617F基因突变阴性患者比较,血细胞计数及常规凝血指标差异有统计学意义(P<0.05)。(3)28例合并血管性疾病的MPN患者中,JAK2V617F基因突变阳性患者的血管性疾病发生率更高(P<0.05或<0.01),且JAK2V617F基因突变阳性患者与JAK2V617F基因突变阴性患者比较,血细胞计数差异有统计学意义(P<0.01)。结论 MPN患者中JAK2V617F基因突变发生率较高,且JAK2V617F基因突变阳性患者的血细胞计数及凝血功能存在明显异常。JAK2V617F突变阳性患者的血栓危险因素如白细胞的升高较阴性者更显著,血管性疾病的发生率更高。初诊MPN患者检测JAK2V617F基因突变、血细胞计数、常规凝血指标可初步评估患者凝血功能,预防血管性并发症的发生。
Objective To investigate the changes of routine blood coagulation function of patients with JAK2V617 F mutation-positive myeloproliferative neoplasms（ MPN） and its relationship with vascular diseases. Methods The clinical data and laboratory examination results of 68 patients with MPN from April 2008 to April 2015 were collected,including 28 patients with complicated vascular diseases（ case group） and 40 patients without vascular diseases（ control group）. The correlation between JAK2V617 F gene mutation and different parameters as well as vascular diseases was retrospectively analyzed. Results Among 68 patients with MPN,there were 45 cases（ 66%） with JAK2V617 F gene mutation,including 27 cases of polycythemia vera（ PV,79%）,16 cases of essential thrombocythemia（ ET,53%） and 2 cases of primary myelofibrosis（ PMF,50%）. There were significant differences in blood cell count and routine blood coagulation parameters between case group and control group（ P〈0. 05 or P〈0. 01）. Moreover there were significant differences in blood cell count and routine blood coagulation parameters between JAK2V617 F mutation- positive patients and JAK2V617 F mutation-negative patients（ P〈0. 05）. Among 28 patients with MPN complicated by vascular diseases,the incidences of vascular diseases in JAK2V617 F mutation- positive patients were significantly higher than those in JAK2V617 F mutation- negative patients（ P〈0. 05 or P〈0. 01）. Conclusion The incidence of JAK2V617 F gene mutation in patients with MPN is relatively higher,moreover,there exist significant abnormalities in blood cell count and blood coagulation function of JAK2V617 F mutationpositive patients. The risk factors of thrombosis pathogenesis in JAK2V617 F mutation- positive patients are more higher than those in JAK2V617 F mutation-negative patients,moreover,the incidences of vascular diseases are relatively higher. To detect JAK2V617 F mutation,blood cell counts and routine blood coagulation parameters in patients with MPN of pr
出处
《河北医药》
CAS
2016年第11期1617-1620,共4页
Hebei Medical Journal
