摘要
目的:探讨氟哌噻吨美利曲辛对更年期房颤合并肠易激综合征的临床治疗效果.方法:选择2011-01/2015-03广西中医药大学第一附属医院收治的女性更年期综合征发生房颤合并肠易激综合征者114例,均实施对症支持处理,精神心理治疗上,对照组使用氟哌噻吨,观察组则使用氟哌噻吨美利曲辛.比较两组治疗前后汉密顿抑郁量表(Hamilton Depression Scale,HAMD)和汉密顿焦虑量表(Hamilton Anxiety Scale,H A M A)评分变化,房颤发生情况及消化系症状变化,P物质(substance P,SP)和神经肽Y(neuropeptide Y,NPY)变化及治疗期间发生的不良反应情况.结果:治疗后观察组HAMD和HAMA评分低于对照组(P<0.05),心房颤动发作次数和排便次数少于对照组(P<0.05),每次持续时间和腹痛时间短于对照组(P<0.05),SP低于对照组(P<0.05),NPY高于对照组(P<0.05),发生口干、心动过速、锥体外系反应及失眠的比例显著低于对照组(P<0.05).结论:氟哌噻吨美利曲辛治疗更年期房颤合并腹泻型肠易激综合征,能显著降低患者焦虑抑郁心理,改善心律失常及消化系症状,并减少不良反应.
AIM：To evaluate the clinical effects of flupentixol melitracen for menopausal atrial fibrillation with irritable bowel syndrome.METHODS：One hundred and fourteen patients with menopausal atrial fibrillation and irritable bowel syndrome treated from January 2011 to March 2015 at the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine were selected.All patients received symptomatic treatment.The control group was additionally given flupentixol,while the observation group was given flupentixol melitracen.Anxiety（HAMD） and depression（HAMA） scores,occurrence of atrial fibrillation,digestive tract symptoms,substance P（SP） and neuropeptide Y（NPY） were compared before and after treatment between the two groups.Adverse reactions occurring during treatment were also compared.RESULTS：After treatment,HAMD and HAMA scores in the observation group were significantly lower than those in the control group（P〈0.05）.Atrial fibrillation episodes and defecation frequency in the observation group were lower than those of the control group（P〈0.05）.Duration time of abdominal pain in the observation group was shorter than that of the control group（P〈0.05）.SP in the observation group was lower than that of the control group（P〈0.05）.NPY in the observation group was higher than that of the control group（P〈0.05）.Incidence rates of mouth dryness,tachycardia,extrapyramidal reactions,and insomnia in the observation group were significantly lower than those of the control group（P〈0.05）.CONCLUSION：Flupentixol melitracen for menopausal atrial fibrillation with irritable bowel syndrome can significantly reduce anxiety and depression,improve cardiac arrhythmias and gastrointestinal symptoms,and reduce adverse reactions.
出处
《世界华人消化杂志》
CAS
2016年第14期2258-2263,共6页
World Chinese Journal of Digestology
关键词
氟哌噻吨美利曲辛
更年期综合征
房颤肠易激综合征
Flupentixol melitracen
Climacteric syndrome
Atrial fi bril ation
Irritable bowel syndrome
