摘要
目的探讨低温可调钠透析联合黄芪注射液对尿毒症合并慢性心功能不全患者透析相关性低血压的临床疗效。方法选择尿毒症合并慢性心功能不全反复发生透析过程中低血压的维持性血液透析患者49例,将其分成两组,其中治疗组25例,对照组24例,对照组在血液透析过程中给予低温(35.5℃),钠曲线透析,治疗组在其基础上加用黄芪注射液40mL持续静脉滴注,观察两组治疗前后血压变化情况及治疗效果。结果治疗组、对照组治疗前收缩压分别为(92.6±8.4)、(89.5±9.0)mm Hg,治疗后分别为(99.9±8.0)、(94.9±9.3)mm Hg,两组治疗前后差异均有统计学意义(t=3.147、2.044,P<0.05),两组治疗后收缩压比较差异有统计学意义(t=2.020,P<0.05)。治疗组、对照组治疗前左室射血分数(LVEF)分别为(45.80±3.62)%、(46.01±3.59)%,治疗后分别为(59.05±3.15)%、(53.85±1.60)%,两组治疗前后差异均有统计学意义(t=13.906、9.847,P<0.05),两组治疗后左心室射血分数差异有统计学意义(t=7.328,P<0.05)。结论低温可调钠透析可以明显降低尿毒症合并心功能不全反复发生透析过程中低血压的发生率,联合黄芪注射液的治疗组更明显地增加了左室射血分数,从而改善了透析患者的左心室功能。
Objective To investigate the effects of low temperature adjustable sodium dialysis combined Astragalus injection in patients with chronic cardiac insufficiency uremia combined the clinical curative effect of dialysis related hypotension. Methods Fourty-nine patients with uremia combined chronic cardiac insufficiency and suffered repeated dialysis hypotension were involved in this study, and they were divided into treatment group（n= 25） and control group（n= 24）. Patients in the control group were treated with hemodialysis for low temperature （35.5 ~C）,and sodium curve dialysis;patients in the treatment group were treated with the same method in that of control group,and they were treated with astragalus injection 40 mL continuous intravenous drip. Then observe the blood pressure changes and treatment effect of the two groups of before and after treatment. Results Systolic pressure of the treatment group and the control group was （92.6±8.4） and （89.5±9.0） mm Hg,and that of after treatment was （99.9± 8.0） and （94.9±9.3） mm Hg respectively, the difference before and after treatment in each group was significant （t= 3. 147, 2. 044, P〈0.05）, and the difference of systolic pressure before and after treatment in each group was significant （t = 2. 020, P〈0.05）. Before the treatment,the left ventricular ejection fraction score of treatment group and control group was （45.80±3.62）% and （46.01 ± 3.59）%, and that of after treatment was （59.05±3.15）% and （53.85 ±1.60） %, respectively, and the difference before and after treatment was significant（t= 13. 906,9. 847 ,P〈0.05） ,and the difference of the left ventricular ejection fraction score after treatment in the two groups was significant （t=7. 328,P〈0.05）. Conclusion For patients with uremia combined chronic cardiac insufficiency and suffered repeated dialysis hypotension,low temperature adjustable sodium dialysis can significantly reduce the incidence of hypotension in the process of dialysis. But com
出处
《重庆医学》
CAS
北大核心
2016年第16期2217-2219,共3页
Chongqing medicine
基金
唐山市科技局研究立项(13130292b)
关键词
低温可调钠
黄芪注射液
血液透析
心功能不全
低血压
low temperature adjustable sodium
astragalus
hemodialysis
cardiac insufficiency
hypotension
