摘要
目的观察在血糖控制已达标的2型糖尿病患者中,自我餐后血糖监测对血糖、血脂、体重和心血管事件可能带来的获益影响。方法选取2012年7月-2014年9月我院收集的124例患者。采用单中心、开放、随机、平行的对照研究,包括≤4 d的筛选期和为期24周的开放治疗期。研究组（每周至少一组7次完整的血糖谱监测,允许自我饮食调整）纳入患者60例,对照组（不需要强制餐后血糖监测,允许空腹血糖监测和自我饮食调整）纳入64例。定期监测血糖,电话随访,主要观察终点是24周时糖化血红蛋白（HbA1c）较基线的变化值。结果经过24周后,研究组的HbA1c、体质量指数（BMI）和三酰甘油（TG）水平较基线显著下降（P均〈0.05）,低密度脂蛋白（LDL）无显著改变（P〉0.05）。对照组的HbA1c、BMI、TG、LDL均无显著性改变（P均〉0.05）。结论积极的餐后血糖监测对血糖控制已达标的患者仍会带来血糖、血脂和体重的进一步受益。
Objective To observe benefits of postprandial blood glucose self-monitoring to blood glucose,blood lipid,body mass index（BMI） and cardiovascular events（CVE） of type 2 diabetic patients with qualified blood sugar control.Methods 124 patients treated in our hospital from July 2012 to September 2014 were selected and randomly divided into study group（n=60） and control group（n=64）.Single-centre,open,random,paralleled control study was adopted,including screening period（≤4 d） and open treatment period（24 weeks）.Patients in the study group were given at least a set（7 times） of blood glucose profile monitoring per week and were permitted to adjust diet by self,while patients in the control group were not given forcefully postprandial blood glucose monitoring and were permitted to perform fasting blood glucose monitoring and to adjust diet by self.The blood glucose of these patients were monitored regularly and followed up by telephone,and the primary end point was change of glycosylated hemoglobin（Hb A1c） level at 24 weeks compared with baseline value. Results After 24 weeks of treatment,the level of Hb A1 c,BMI,and triglyceride（TG） in the study group were significantly lower than those at baseline（P〈0.05）,but there was no significant difference in low density lipoprotein（LDL）（P〈0.05）.In the control group,there were no significant differences in Hb A1 c,BMI,TG and LDL between 24 weeks of treatment and at baseline（P〉0.05）. Conclusion Positive postprandial blood glucose monitoring can bring further benefits to blood glucose,blood lipid,and BMI in type 2 diabetic patients with qualified blood glucose control.
出处
《中国当代医药》
2016年第14期31-33,37,共4页
China Modern Medicine
关键词
2型糖尿病
餐后血糖
自我血糖监测
随机对照研究
Type 2 diabetes Postprandial blood glucose Self-monitoring of blood glucose Randomized controlled trial
