摘要
目的观察不同剂量瑞舒伐他汀治疗急性冠状动脉综合征患者的治疗效果及对患者血脂、血清高敏C反应蛋白(hs-CRP)的影响。方法采用随机数字表法将96例急性冠状动脉综合征患者分为低剂量组和高剂量组,每组48例;低剂量组患者在常规治疗基础上给予瑞舒伐他汀10 mg·d^(-1),高剂量组患者在常规治疗基础上给予患者瑞舒伐他汀20 mg·d^(-1),比较2组患者近期心血管不良事件、血脂和血清hs-CRP水平变化情况。结果治疗后7 d,2组患者总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)均较治疗前显著下降(P<0.05);治疗后30 d,2组患者三酰甘油(TG)、TC和LDL均较治疗前显著下降,高密度脂蛋白胆固醇(HDL)较治疗前显著升高(P<0.05);与治疗7 d时比较,治疗后30 d低剂量组患者TC、LDL显著下降(P<0.05),高剂量组患者TC、LDL显著下降(P<0.05),HDL显著升高(P<0.05),高剂量组患者TC和LDL较低剂量组下降显著,HDL较低剂量组升高显著(P<0.05)。治疗后7、30 d,2组患者hs-CRP水平均较治疗前显著下降,且30 d时下降更加显著(P<0.05);高剂量组患者治疗后7、30 d hsCRP水平均较低剂量组下降显著(P<0.05)。2组患者治疗期间不良反应发生率比较差异无统计学意义(P>0.05),但高剂量组患者治疗期间心血管不良事件发生率低于低剂量组(P<0.05)。结论对急性冠状动脉综合征患者实施瑞舒伐他汀强化治疗可有效抑制机体炎症反应,有利于改善患者预后,提高患者生存质量。
Objective To observe the treatment effectiveness of different dose of rosuvastatin for treatment of patients with acute coronary syndrome and analyse the effect of rosuvastatin on the levels of blood lipid and serum high-sensitivity C-reactive protein（ hs-CRP）. Methods A total of 96 patients with acute coronary syndrome were randomly divided into low-dose group and high-dose group by digital table method,with 48 patients in each group. The patients in low-dose group were given rosuvastatin 10 mg · d^（-1）in addition to conventional therapy; the patients in high-dose group were given rosuvastatin20 mg·d^（-1）. The recent cardiovascular adverse events,the changes of blood lipids and serum hs-CRP were compared between the two groups. Results Compared with before treatment,the levels of total cholesterol（ TC） and low-density lipoprotein cholesterol（ LDL） were significantly decreased after 7-day treatment（ P 0. 05） in two groups; after 30-day treatment,triglyceride（ TG）,TC and LDL significantly decreased（ P 0. 05）,while the level of high-density lipoprotein cholesterol（ HDL） increased（ P 0. 05）. Compared with the results of 7 days after treatment,the levels of TC,LDL in low-dose group and high-dose group patients were decreased（ P 0. 05）; the HDL level in high-dose group was increased at 30 days after treatment（ P 0. 05）.The levels of TC and LDL in high-dose group were lower than low-dose group（ P 0. 05）; but the HDL level was higher than low-dose group（ P 0. 05）. Compared with before treatment,the hs-CRP levels decreased at 7,30 days after threatment in the two groups（ P 0. 05）; and the hs-CRP levels at 30 days after treatment were lower than those at 7 days after threatment in the two groups（ P 0. 05）. The hs-CRP level in high-dose group was significantly lower than that in low-dose group at 7,30 days after treatment（ P 0. 05）. There was no statistic difference of incidence of adverse events between the two groups（ P 0. 05）.The incidence of card
出处
《新乡医学院学报》
CAS
2016年第5期397-399,402,共4页
Journal of Xinxiang Medical University
