摘要
目的探讨雄激素受体（AR）在三阴性乳腺癌组织中的表达特征及其对临床结局的预测价值。方法纳入自2008年1月至2010年1月接受手术治疗的原发性乳腺癌女性患者568例。对手术切除标本的组织切片进行雌激索受体（ER）、孕激素受体（PR）和人表皮生长因子2受体（HER2）免疫组化染色，根据结果判定为三阴性乳腺癌和非三阴性乳腺癌。收集三阴性乳腺癌患者的年龄、家族史、月经情况、肿瘤大小、肿瘤分期、肿瘤分级、肿瘤病理类型、淋巴结转移等资料用于临床分析。对三阴性乳腺癌患者的组织切片行AR免疫组化分析，对AR表达阳性与阴性患者采用Kaplan-Meier法进行生存分析比较，采用Log．rank检验比较AR表达与5年总存活和无瘤存活率之间的相关性。结果在568例乳腺癌患者中，确认174例（30．6％）为三阴性乳腺癌患者，其中84例AR表达阴性，90例AR表达阳性。在5年随访期间，AR阴性组复发转移率为35．7％（30／84），AR阳性组为20．0％（18／90）；AR阴性组5年总存活率为73．8％，AR阳性组为81．1％。AR阳性表达与5年内死亡以及5年内肿瘤复发的风险未显示有相关性，校正年龄、月经情况、肿瘤大小和淋巴结转移因素之后，AR表达阳性与5年内死亡以及5年内肿瘤复发风险下降相关，5年总存活校正风险比为0．794，95％CI为0．430-1．021；5年无瘤存活校正风险比为0．722，95％CI为0．451-0．965。结论AR表达阴性与死亡和复发风险增加相关，可用于预测不良结局。
Objective To investigate androgen receptor （AR） expression in triple negative breast cancer（TNBC） patients and its predictive value for clinical outcomes. Methods Five hundred and sixty-eight primary breast cancer patients who received surgery treatment from January 2008 to January 2010 were included in this study. Tissue sections Of surgical resection specimens were underwent estrogen receptor （ER）, progesterone receptor （ PR）, and human epidermal growth factor receptor 2 （ HER2 ） immunohisto chemical staining, according to the judgment for triple negative breast cancer and non triple negative breast cancer. Data on age, family history, menstruation, tumor size, tumor stage, tumor grade, pathological type and lymph node metastasis were collected for analysis. Immunohistochemical analysis of AR was done in tissue sections of triple negative breast cancer patients, Kaplan-Meier method was used to compare survival between AR（＋） and AR（-） groups, and Log-rank method was used to determine the association between AR- positive expression and 5-year overall survival as well as disease free survival. Results Among 568 breast cancer patients, 174 （30. 6%） TNBC patients were identified, including 84 patiens with AR （-） expression and 90 patients with AR （ ＋ ） expression. During 5 years＇ follow-up,reccurrence rate was 35.7% （30/84） in AR（-） group and 20. 0% （ 18/ 90） in AR （＋） group; 5-year overall survival rate was 73.8% in AR （-） group and 81. 1% in AR （＋） group. There was no significant association between AR（＋） expression and 5-year death or recurrence rate, while after adjusting for age,menstruation,tumor size and lymph node metastasis,AR（＋） expression was significantly associated with decreased 5-year death and recurrence rate, adjusted hazard ratio（HR） was 0. 794,95CI （0. 430- 1. 021） and 0. 722, 95CI （ 0. 451-0. 965 ） respectively. Conclusion AR （ - ） expression is associated with increased risk of death and recurre
出处
《中国综合临床》
2016年第5期440-443,共4页
Clinical Medicine of China
关键词
三阴性乳腺癌
雄激素受体
雌激素受体
孕激素受体
人表皮生长因子2受体
存活率
Triple negative breast cancer
Androgen receptor
Estrogen receptor
Progesterone receptor
Human epidermal growth factor receptor 2
Survival rate
