摘要
目的探讨大剂量甲泼尼松龙冲击疗法治疗视神经脊髓炎的临床效果。方法选取2013年1月至2014年5月接受治疗的视神经脊髓炎患者80例，按照自愿原则，将其均分为对照组和观察组，每组各40例。观察组采用大剂量甲泼尼松龙冲击疗法进行治疗（静脉注射甲泼尼松龙针剂配合葡萄糖注射液4d、口服泼尼松片剂），对照组采用静脉缓慢注射地塞米松，之后口服泼尼松片剂。比较两组患者的神经功能恢复时间[包括患者肌力增加Ⅱ级所需的时间；恢复括约肌功能（排便、排尿功能）所需的时间；患者视力提高Ⅱ级所需时间以及治疗效果]以及治疗有效率。结果观察组患者的肌力增加Ⅱ级所需时间为（6．12±3．21）d，对照组为（13．11±5．37）d：观察组恢复括约肌功能（排便、排尿功能）所需的时间为（9．98±6．97）d，对照组为（17．36±7．14）d；观察组视力提高Ⅱ级所需的时间为（7．10±4．22）d，对照组为（12．95±4．98）d，观察组的神经功能恢复情况明显优于对照组（P〈0．05）。观察组有效率95．00％，对照组有效率80．00％，观察组的治疗效果明显高于对照组（P〈0．05）。结论采用大剂量甲泼尼松龙冲击疗法治疗视神经脊髓炎能快速促进患者神经功能的恢复，提高治疗有效率，减轻患者的痛苦，疗效显著。
Objective To explore the effect of the large dose shock therapy of methylprednisolone for treatment of optic nerve osteomyelitis. Methods 80 cases of patients with osteomyelitis of the optic nerve from January 2013 to May 2014 in our hospital wer enrolled, in accordance with the principle of voluntary, and were divided into control group and experimental group, the observation group received high dose mcthylprednisolone shock therapy treatment （ intravenous armour prednisone with 4d glucose injection, a 4d prednisolone injection with glucose injection, oral prednisone tablets ） , while the control group received intravenous injection of dexamethasone slowly, after oral prednisone tablets. Compared two groups of patients with neurological recovery time （ include： the time needed for muscle strength increased in patients with grade 2; restore sphincter fimction （ defecation and urination function ） ; the time needed for patients with vision to improve the effect of the time needed for level 2 and treatment ） as well as the treatment effectiveness. Results The patients of observation group muscle strength increases the time needed for level 2 （ 6.12 ± 3.21 ） days, the control group （ 13.11±5.37 ） days; Observation group restore sphincter function （ defecation and urination function ） the time required for （ 9.98 ± 6.97 ） days, the control group （ 17.36 ±7.14 ） days; Observation group vision increase the time needed for level 2 （ 7.10 ± 4.22 ） days, the control group （ 12.95± 4.98 ） days, and neural function recovery ofobservation group was obviously better than the control group （ P〈0.05 ） . The effective rate of the observation group was 95.00%, the effective rate in control group was 80.00%, the treatment effect of observation group was obviously higher than that of control group （ P〈0.05 ） . Conclusion The high doses of methylprednisolone shock therapy to treat patients with optic nerve osteomyelitis can quickly promote the recovery of neural fianction
出处
《浙江临床医学》
2016年第6期1041-1042,共2页
Zhejiang Clinical Medical Journal
关键词
大剂量甲泼尼松龙冲击疗法视
神经脊髓炎
临床研究
Large dose methylprednisolone shock therapy
The optic nerve osteomyelitis
Clinical research
