摘要
目的观察中西医结合治疗膝骨关节炎(KOA)的临床疗效。方法纳入2012年1月-2015年6月诊治的180例KOA患者,随机分为3组,中医组(A组,n=60)针灸配合特定电磁波治疗器照射治疗;西医组(B组,n=60)口服盐酸氨基葡萄糖片、膝关节腔内注射玻璃酸钠;中西医结合组(C组,n=60)为在A组的方法上同时加用B组的治疗方法;疗程均为6周。分别于治疗前和治疗后2周末、治疗结束时及治疗结束后5个月末,评定西安大略和麦克马斯特大学骨关节炎指数(WOMAC评分)和总有效率。结果治疗后各组WOMAC评分差异有统计学意义(P<0.05);总有效率A组78.33%,B组83.33%,C组91.67%;C组与A组、C组与B组比较总有效率,差异均有统计学意义(P<0.05),A、B组总有效率比较差异亦具有统计意义(P<0.05)。不良反应A组2例,B组2例,C组2例;均较轻微,无严重不良事件发生。结论中医、西医治疗KOA均安全、有效,联合应用时,疗效进一步增强,不良反应未增加。
Objective To observe the clinical effect of combined traditional Chinese and Western medicine in the treatment of knee osteoarthritis （KOA）. Methods A total of 180 KOA patients treated between January 2012 and June 2015 were randomly assigned to 3 groups： Chinese medicine group （group A, n=60） with acupuncture and irradiation therapy of specific electromagnetic wave therapeutic apparatus, western medicine group （group B, n=60） with oral glucosamine hydrochloride tablets and knee joint cavity injection of sodium hyaluronate, and integrated traditional Chinese and Western medicine group （group C, n=60） with treatments combining those in both group A and B. The treatment course was 6 weeks. The Western Ontario ＆ McMaster University （WOMAC） osteoarthritis index score and total effective rate were evaluated before treatment and 2 weeks after treatment, end of treatment and 5 months after treatment. Results After treatment, the average improvement of WOMAC scores in the three groups was significantly different （P 〈 0.05）. The total effective rate was 78.33% in group A, 83.33% in group B, and 91.67% in group C. The difference of total effective rate between group C and A, and between group C and B was statistically significant （P 〈 0.05）; and it was also statistically significant between group A and B （P 〈 0.05）. There were two cases of adverse reactions in group A, two in group B, and two in group C, and the reactions were all relatively mild without any serious adverse events. Conclusions Chinese medicine and western medicine are both effective and safe for the treatment of KOA. When they are combined, the effect is further enhanced with no increase of adverse reactions.
出处
《华西医学》
CAS
2016年第5期811-815,共5页
West China Medical Journal
关键词
骨关节炎
膝
中西医结合
针灸
特定电磁波治疗器
盐酸氨基葡萄糖片
玻璃酸钠
Osteoarthritis, knee
Integrated traditional Chinese and Western medicine
Acupuncture
Specializedelectromagnetic wave therapeutic apparatus
Glucosamine hydrochloride
Sodium hyaluronate
