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健步通络熏蒸液对膝骨性关节炎大鼠血清和关节液中IL-1β、MMP-3的影响 被引量:4

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摘要 目的:观察健步通络熏蒸液对膝骨性关节炎大鼠血清和关节液中白介素1β(IL-1β)、基质金属蛋白酶3(MMP-3)含量的影响及其相关性,探讨健步通络熏蒸液治疗膝骨性关节炎的作用机制。方法:将32只大鼠随机分为四组,分别为A正常组、B模型组、C对照组、D治疗组,B、C、D三组按照Hulth造模方法造成膝骨性关节炎模型。治疗组给予健步通络熏蒸液治疗,对照组给予扶他林外涂。给药10天后测定大鼠血清和关节液中白介素1β、基质金属蛋白酶3含量。结果:对血清、关节液IL-1β、MMP-3指标比较,治疗组、对照组均低于模型组,差异有统计学意义(P<0·05);模型组明显高于正常对照组,差异有显著的统计学意义(P<0·01);治疗组与对照组在上述指标两组间比较无明显性差异(P>0·05)。结论:采用Hulth造模法可以制造出膝骨性关节炎动物模型;膝骨性关节炎可以导致大鼠血清、关节液中IL-1β、MMP-3含量升高,IL-1β、MMP-3可能是参与0A发病过程的重要介质;健步通络熏蒸液、扶他林均具有降低血清、关节液中IL-1β、MMP-3含量,在一定程度上对膝骨性关节炎有治疗作用。
出处 《四川中医》 2011年第11期17-19,共3页 Journal of Sichuan of Traditional Chinese Medicine
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