摘要
目的观察静脉注射小剂量抗组胺药盐酸异丙嗪对芬太尼诱发咳嗽的影响。方法选200例拟行全身麻醉择期手术患者,术前分为4组:对照组和试验1、2、3组,麻醉诱导前各组分别给予0.1 mL/kg的4种药液:0.9%盐水,0.5、1.0、1.5mg/mL异丙嗪,所有患者麻醉诱导注射芬太尼3μg/kg,记录注射芬太尼2min内患者咳嗽发生情况,包括咳嗽发生次数、强度、时间以及收缩压、舒张压、心率情况。结果试验1、2、3组咳嗽发生率为16%、12%、10%,与对照组(32%)相比明显下降(P<0.05);试验1、2、3组轻度咳嗽发生率与对照组相比明显下降(P<0.05);各组中度和重度咳嗽发生率比较差异无统计学意义(P>0.05);发生咳嗽的平均时间4组比较差异无统计学意义(P>0.05)。T4时点对照组、试验2组、试验3组的舒张压升高较试验1组明显,差异有统计学意义(P<0.05),试验3组心率增快高于对照组和试验1组、试验2组,差异有统计学意义(P<0.05)。结论预注盐酸异丙嗪可降低芬太尼诱发咳嗽的发生率。
Objective To observe the effect of intravenous injection of small dose of promethazine hydrochloride on fentanyl induced cough（FIC）during general anesthetic induction.Methods Two hundred elective operation patients undergoing general anesthesia were selected and divided into 4groups before operations：control group,experimental group1,2and 3.Four drugs（0.9%NS,0.5 mg/mL promethazine hydrochloride,1.0 mg/mL promethazine hydrochloride,1.5 mg/mL promethazine hydrochloride）with a dose of 0.1mL/kg were injected before induction respectively.All patients were inducted by intravenous injection of fentanyl3μg/kg.The occurrence of cough was recorded,including onset time,frequency and intensity of cough within two minutes after injection of fentanyl,as well as SBP,DBP,HR of four groups.Results The total incidence of cough in experimental group 1,2,3（16%,12%,10%）was significantly lower than that in control group（32%,P〈0.05）.The incidence of mild cough in experimental group 1,2,3 was significantly lower than that in control group（P〈0.05）.There were no significant differences among all the groups in the incidence of moderate cough and severe cough（P〈0.05）.There were no significant differences of average occurrence time of FIC among all the groups（P〈0.05）.After endotracheal intubation,the DBP of experimental group 2,3and control group were higher than that of experimental group 1（P〈0.05）,the HR of experimental group 3were highest in four groups（P〈0.05）.Conclusion Pre-injection of promethazine hydrochloride could decrease the incidence of FIC.
出处
《重庆医学》
CAS
北大核心
2016年第15期2090-2091,2094,共3页
Chongqing medicine
关键词
异丙嗪
芬太尼
咳嗽
组胺
麻醉药
promethazine
fentanyl
cough
histamine
anesthetics
