摘要
目的探讨血清血中管内皮细胞钙黏蛋白(VE-cadherin)与妊娠期糖尿病的关系及临床意义。方法采用酶联免疫吸附法(ELISA)测定140例妊娠期糖尿病患者(包括空腹血糖高60例,服糖后血糖高、空腹及服糖后血糖均高各40例)及60例正常对照组产妇血清VE-cadherin含量。结果妊娠期糖尿病组及对照组血清中VE-cadherin均有表达,VE-cadherin在3组妊娠期糖尿病患者血清中含量与正常对照组比较,差异有统计学意义(t=3.29,2.94,3.35,P值均<0.05)。VE-cadherin水平在3组糖尿病患者之间差异有统计学意义(t=2.83,2.29,P均<0.05)。结论 VE-cadherin的高表达说明妊娠期糖尿病患者有内皮细胞损伤,VE-cadherin在妊娠期糖尿病发病机制中发挥重要作用。
Objective To investigate the relationship and significance of VE-cadherin intravenous serum of gestational dia-betes mellitus women. Methods Contents of VE-cadherin in intravenous serum from 140 gestational diabetes mellitus pa-tients which were divided into elevation of fasting glucose level 60,elevation of plasma glucose after oral glucose （75 g） tol-erance test （OGTT） 40 and elevation of fasting glucose level and plasma glucose after OGTT 40 patients were detected by enzyme-linked immunosorbent assay （ELISA） respectively. 60 normal pregnant women were taken as control group. Results VE-cadherin expressed in both patients and controls. Serum contents of VE-cadherin in patients and controls had signifi-cant difference by comparison （t=3.29,2.94,3.35,all P〈0.05）. Moreover,there were differences among the contents of three groups （t=2.83,2.29,P〈0.05）. Conclusion The high expression of VE-cadherin in gestational diabetes mellitus patients in-dicates the injury of vascular endothelium cells and VE-cadherin plays an important role in the pathogenesis of gestational diabetes mellitus.
出处
《糖尿病新世界》
2016年第6期80-81,126,共3页
Diabetes New World Magazine
基金
江苏省科技计划项目(SGG20120098)
