摘要
目的研究不同年龄、麻疹病史及麻疹疫苗接种史对孕妇静脉血麻疹病毒(MV)IgG抗体水平的影响,为预测母传抗体对其婴幼儿的保护作用提供科学的理论依据。方法选取2013年2月至2015年2月来广东省深圳市福田区妇幼保健院产科分娩,且符合纳入排除标准的217例孕妇作为研究对象,采用酶联免疫吸附试验(ELISA)定量检测孕妇静脉血中MV IgG抗体水平。结果不同年龄组之间的麻疹IgG抗体几何平均浓度(GMC)均高于阳性值同时均低于有效保护值,且差异均无统计学意义(P>0.05);不同年龄组之间的MV IgG抗体的阳性率与保护率经比较差异均无统计学意义(P>0.05)。有MV疫苗接种史的孕妇其血清MV IgG抗体的GMC明显低于有MV病史的孕妇其血清MV IgG抗体的GMC,且两组GMC差异有统计学意义(P<0.05);MV疫苗接种史组的保护率(37.9%)明显低于MV病史组的保护率(85.7%),且差异具有统计学意义(P<0.05);其余指标检测差异均无统计学意义(P>0.05)。结论年龄对孕妇体内MV IgG抗体无显著影响;不论是具有麻疹病史或麻疹疫苗接种史,其孕妇静脉血麻疹IgG抗体GMC对婴儿的保护率低,建议育龄妇女孕前再次接种麻疹疫苗。
Objective To study the effect of different ages,history of measles and measles vaccination（MV）history on IgG antibody levels of pregnant women,and to provide a scientific theoretical basis for predicting the protective effects of maternal antibody on the infants.Methods A total of 217 pregnant women from February 2013 to February 2015 in obstetrics of our hospital were selected as study objects,MV IgG antibody levels in venous blood of pregnant women were detected by enzyme linked immunosorbent assay（ELISA）.Results The IgG antibody geometric mean concentration（GMC）of the different groups were all higher than the positive values and lower than effective protection,but there was no statistically significant difference（P〉0.05）;the differences of positive rates and the protective rates of MV IgG antibody between the different groups were not statistically significant（P〉0.05）,either.The serum IgG GMC antibody in pregnant women with MV vaccination history was significantly lower than those with MV history of IgG,and the difference between the two groups was statistically significant（P〈0.05）;the protective rate（37.9%）of MV vaccine group was significantly lower than that of MV（85.7%）（P〈0.05）;there was no statistical significance in the detection of the remaining indicators（P〉0.05）.Conclusion Age has no significant effect on MV IgG antibody of pregnant women.Whether pregnant women has history of measles or history of measles vaccination,the level of IgG antibody GMC of vein blood measles has a low protective rate to the infants,so it is suggested that women should vaccine again before pregnancy.
出处
《国际检验医学杂志》
CAS
2016年第10期1352-1354,共3页
International Journal of Laboratory Medicine
基金
深圳市福田区卫生公益性科研项目(FTWS201335)
关键词
孕妇
麻疹病毒
IGG抗体
pregnant women
measles virus
IgG antibody
