摘要
目的探讨肝吸虫病患者的性别、年龄及相关生化指标的特征,并探讨嗜酸性粒细胞百分率（EOS%）联合γ-谷氨酰转肽酶（GGT）对可疑肝吸虫卵感染者的早期诊断是否具有临床诊断意义。方法以2013年1月至2014年12月在中山市人民医院检验医学中心粪便镜检出肝吸虫卵的患者共1 679例为观察组,回顾性统计其性别、年龄,白细胞计数（WBC）、嗜酸性粒细胞（EOS）、EOS%、丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）和GGT等指标。另同期随机选取635例健康者作为对照组,分析并比较两组性别、年龄及相关生化指标的差异。结果肝吸虫病检出率中男性远高于女性,其高发年龄段集中在40~69岁,尤以50~59岁和60~69岁组居多;观察组的WBC、EOS、EOS%、ALT、AST和GGT指标均显著高于对照组,且差异具有统计意义（P〈0.05）。1 679例肝吸虫病中,734例出现EOS%增高,992例出现肝功能异常（其中GGT升高者为619例）,EOS%和（或）GGT升高者为1 075例,而EOS%和GGT同时升高者只占271例。结论 40~69岁男性是肝吸虫病的易感人群,对于临床上不明原因的EOS%升高和（或）肝功能异常者应高度警惕肝吸虫卵感染,可多次送检粪便,从而提高肝吸虫卵的镜检率,降低漏诊率。
Objective To analyze the clinical and laboratory features of clonorchiasis and to investigate the significance of combining EOS% and GGT in early diagnosis of patients with suspected infection of the liver fluke eggs.Methods The data of 1 679 patients with clonorchiasis were collected and retrospectively analyzed,which included gender,age,WBC,EOS,EOS%,ALT,AST and GGT,and 635 cases of healthy subjects during the same period as control group.Then the differences of the indicators between the two groups were statistically analyzed.Results The detection rate of liver fluke disease in males was significantly higher than of females,and the incidence of the intection was high in the age of 40 to 69years,especially in the 50 to 59years and 60 to 69years group.Compared with the control group,the level of WBC,EOS,EOS%,ALT,AST and GGT were higher in the clonorchiasis group,the difference was statistically significant（P〈0.05）.The level of EOS%increased in 734 patients,and abnormal liver function was noticed in 992 cases.1 075 cases exhibited either a higher level of EOS% and（or）GGT levels.Only 271 cases exhibited a simultaneous higher level of EOS% and GGT levels.Conclusion The 40 to 69years old males are the susceptible population for clonorchiasis.People experiencing unexplained clinically rise of EOS%levels and（or）abnormal liver function should be highly alert to liver fluke eggs infection.Repeated inspection of feces can improve liver fluke eggs microscopic rate and reduce the misdiagnosis and missed diagnosis of clonorchiasis.
出处
《国际检验医学杂志》
CAS
2016年第10期1332-1334,共3页
International Journal of Laboratory Medicine
