摘要
大量研究表明生命早期不良刺激与成年期的高血压的发生密切相关，在此基础上，有学者提出血压的“发育程序化”理论。肾素-血管紧张素系统是机体维持血压和心血管稳态的重要调节系统，而且在胚胎组织器官的发生发育中发挥重要作用。生命早期不良环境的刺激可在循环、组织局部等多水平影响肾素-血管紧张素系统的表达，进而影响其调节平衡，并调控后期的血压。该文就生命早期不良刺激对肾素-血管紧张素系统影响及其与高血压发育程序化的关系展开综述。
Numerous studies have proved the close relationship between early adverse exposure and hy- pertension in later life, as a result, the blood pressure ＂developmental programming＂ theory has been proposed. The renin-angiotensin system（RAS） is an important endocrine system for maintaining blood pressure and cardio- vascular homeostasis, which also plays a key role in histogenesis in early period. Adverse environmental exposure in early life influences the expression of RAS in circulation and local tissue, and interferes the balance of RAS, therefore regulates the blood pressure in later life. This review focuses upon the influence of RAS by early ad- verse exposure, the relation between RAS and developmental programming for hypertension.
出处
《国际儿科学杂志》
2016年第5期350-354,共5页
International Journal of Pediatrics
基金
江苏省自然科学基金（BK2012603）
