摘要
目的:基于液固压缩技术制备黄芩苷固体自微乳化释药系统。方法:运用液固压缩技术,通过载体材料的筛选,体外溶出度的测定,筛选黄芩苷固体自微乳化释药系统的最佳处方。结果:以微晶纤维素为载体材料,溶出50%,仅需要6.4min,明显优于原料药和市售片。结论:运用液固压缩技术制备黄芩苷固体自乳化释药系统,方法简单,且可很好改善黄芩苷的溶出。
Objective： To prepare baicalin solid self micro-emulsifying drug delivery systems by liquidsolid compression techniques. Method： Liquidsolid compression technique was used. By screening carrier material and detection of in vitro dissolution, the best prescription of baicalin solid self micro-emulsifying drug delivery system was optimized. Result： Microcrystalline cellulose as cartier material, 50% preparation was dissolved in 6.4 min which was significantly better than crude drug and commercial tablet. Conclusion： The method of preparing baicalin solid self-emulsifying drug delivery system using liquidsolid compression technique is simple, and can improve baicalin dissolution.
出处
《中药与临床》
2016年第1期23-26,共4页
Pharmacy and Clinics of Chinese Materia Medica
基金
四川省教育厅重点项目(15ZA0094)
关键词
固体自微乳化释药系统
液固压缩技术
黄芩苷
Solid self micro-emulsifying drug delivery systems
liquidsolid compression techniques
baicalin
