摘要
目的:探讨红细胞体积分布宽度(RDW-CV)、血清神经元特异性烯醇化酶(NSE)、和促红细胞生成素(EPO)动态检测在新生儿缺氧缺血性脑病(HIE)中的临床意义。方法:电化学发光法检测82例缺氧缺血性脑病新生儿出生1 d、3 d、7 d和第10 d血清中NSE,EPO的含量变化,及各时段红细胞RDW-CV。选40例健康足月新生儿为对照。结果:HIE组出生1 d血清NSE、EPO的水平(39.5±6.81 ng/L 126.2±32.5 m IU/m L)明显高于对照组(9.61±2.42 ng/L、13.5±4.2 m IU/m L P<0.01),第7 d时有所下降,与对照组比较有显著性差异(P<0.05);RDW-CV在第1 d明显高于对照组(19.6±9.0 P<0.01),第10 d明显下降,与对照组比较无显著性差异(P>0.05)。结论:HIE患儿生后脑损伤越重,血NSE、EPO和RDW-CV越高,随病情恢复进行性降低;该三项指标的检测对准确了解脑损伤有重要意义。
Objective：To investigate the clinical significance of red blood cell volume distribution width （ RDW - CV ） , serum neuron specific enolization enzyme （ NSE ） , and the dynamics of erythropoietin（ EPO） dynamic detection in neonatal hypoxic ischemic encephalopathy（ HIE） . Methods：82 cases of newborn hypoxic ischemic encephalopathy in 1 d,3 d,7 and 10 d were examined by elec-trochemical luminescence detection of serum NSE,the variation in content of EPO,and the red blood cells RDW-CV in each period. 40 healthy full-term newborns were selected as the control. Results：The levels of serum NSE,EPO（39. 5±6. 81 ng/L 126. 2±32. 5 mIU/mL）in HIE1 day born group were significantly higher than the control group （ 9 . 61±2 . 42 ng/L 、13 . 5±4 . 2 mIU/mL P〈0 . 01 ） , and a drop in the 7 day,compared with the control group with significant difference（P〈0. 05）;RDW-CV in 1 day was significantly higher than control group （ 19 . 6±9 . 0 P〈0 . 01 ） , in the 10 day significantly decreased,compared with the control group there was no significant difference（P〉0. 05）. Conclusion：The children with HIE have braindamage more severe,the higher the levels of NSE,EPO and RDW-CV,with the decreasing when the illness recovery;The detection of the three indicators are important for accurate understanding of brain damage.
出处
《内蒙古医科大学学报》
2016年第1期50-53,共4页
Journal of Inner Mongolia Medical University
基金
内蒙古自治区教育厅高等学校科学研究项目重大课题(NJZZ13411)
