摘要
目的:观察"肺感2方"治疗多重耐药菌(multi-drug resistant organisms,MDRO)肺部感染的临床疗效。方法:67例MDRO肺部感染患者随机分为观察组34例和对照组33例。对照组根据多重耐药细菌药敏结果选择抗生素治疗及对症支持治疗,观察组在对照组基础上给予"肺感2方",并观察疗效及不良反应,2周为1个疗程。结果:治疗后2周观察组及对照组在急性生理与慢性健康评分(acute physiology and chronic health evaluation,APACHEⅡ评分)、降钙素原(procalcitonin,PCT)、C反应蛋白(C reactive protein,CRP)及氧和指数均有改善,观察组APACHEⅡ评分、PCT及氧合指数分别为(11.82±7.19)分、(0.49±0.34)μg·L^(-1)、(331.23±35.25),对照组APACHEⅡ评分、PCT及氧合指数分别为(15.31±6.76)分、(0.86±0.62)μg·L^(-1)、(312.53±20.25),两组比较,差异均有统计学意义(P<0.05)。两组治疗后CRP均较治疗前明显改善(P<0.05),但两组治疗后比较,差异无统计学意义(P>0.05)。观察组患者细菌清除率为77.78%,对照组为52.94%,两组比较,差异有统计学意义(P<0.05)。对照组有效率为69.70%,观察组为91.18%,两组比较,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:"肺感2方"治疗多重耐药菌肺部感染临床疗效显著。
Objective： To observe the clinical effect of two TCM decoctions in treatment of pulmonary patients with multi drug-resistant bacteria infection. Method： 67 patients with multi drug-resistant bacterial lung infection were randomly divided into observation group and control group,with 34 cases and 33 cases respectively. The control group only received routine medicine treatment while the observation group had been treated with two TCM decoctions in addition to the routine medicine treatment as that in the control group. The course of the both kinds of treatment is 14 days. Results： After 2 weeks treatment applied to the treatment group and control group,the acute physiology and chronic health evaluation（ APACHE） score,PCT,C-reactive protein（ CRP） and PaO_2/FiO_2of the two groups were improved. The APACHEⅡ score,PCT and oxygenation index of the observation group were（ 11. 82 ±7. 19） points,（ 0. 49 ± 0. 34） μg·L^（-1）and（ 331. 23 ± 35. 25） respectively,while the APACHEⅡ score,PCT and oxygenation index of the control group were（ 15. 31 ± 6. 76）,（ 0. 86 ± 0. 62） μg·L^（-1）and（ 312. 53 ± 20. 25） respectively. The differences between the two groups were statistically significant（ P〈0. 05）. Both CRP of the two groups after treatment got significantly improved than before（ P〈0. 05）,but the difference between the two groups was not statistically significant（ P〉0. 05）. The bacterial clearance was 77. 78% in the observation group while that was 52. 94% in the control group,with the difference was statistically significant（ P〈0. 05）. The efficacy rate of the control group was 69. 70% while that of the observation group was 91. 18%,with the difference being statistically significant（ P〈0. 05）. The the difference of the adverse reaction incidence was not statistically significant（ P〉0. 05）. Conclusion： Two TCM decoctions in treatment of pulmonary patients with multi drug-resistant bacteria infection have good curative effect.
出处
《中医学报》
CAS
2016年第5期642-645,共4页
Acta Chinese Medicine
基金
广东省科技厅项目{粤科规划字[2013]137号-100}
关键词
“肺感2方”
多重耐药菌
肺部感染
two TCM decoctions
multiple resistant bacteria
pulmonary infection
