摘要
本文先介绍糖皮质激素及其受体在肝衰竭发生与发展中的作用;然后介绍糖皮质激素通过抑制免疫应答而阻止原发性肝损伤、内毒素/TNFα等细胞因子介导的继发性肝损伤的机制;最后介绍糖皮质激素增强肝细胞保护、阻止肝细胞死亡的机制。
Firstly, the role of glucocorticoids and its receptor in the development and progress of liver failure were reviewed. Secondly, the mechanisms of glucocorticoids in preventing primary liver injury via inhibition of immune response and scondary liver injury induced by endotoxins and TNFα were introduced. Finally, the mechanisms of glucocorticoids in enhancing hepatoprotection and preventing hepatocytes death were reviewed.
出处
《胃肠病学和肝病学杂志》
CAS
2016年第5期481-484,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
国家自然科学基金面上项目(81270525)
关键词
肝衰竭
糖皮质激素
受体
乙型肝炎病毒
Liver failure
Glucocorticoids
Receptor
Hepatitis B virus
