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CD64、PCT及hs-CRP在卒中相关性肺炎诊断中的作用 被引量:12

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摘要 目的探讨卒中患者血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平及中性粒细胞CD64指数在卒中相关性肺炎(SAP)诊断中的作用。方法收集2014年1月至2015年7月该院神经内科住院卒中患者85例,根据卒中后发生肺炎时间将患者分为早发SAP组29例和晚发SAP组25例,另有卒中无合并肺炎患者31例作为对照组。使用荧光免疫分析仪检测患者血清PCT、超敏C反应蛋白(hs-CRP)水平,流式细胞术(FCM)检测CD64指数,并计算临床肺部感染评分(CPIS),随后进行统计学处理。结果晚发SAP组CD64指数显著高于早发SAP组和对照组(P<0.05);早发SAP组的PCT水平显著高于晚发SAP组和对照组(P<0.05),且CD64指数、PCT、白细胞计数、CPIS和hs-CRP组内差异有统计学意义(P<0.05)。联合CD64指数、PCT和hs-CRP对早发SAP组和晚发SAP组敏感性和特异性均高于单一指标。结论 3项指标在SAP患者中均显著升高,且具有高敏感性和高特异性;可作为SAP诊断及早发、晚发SAP鉴别诊断的指标。
出处 《检验医学与临床》 CAS 2016年第9期1239-1241,共3页 Laboratory Medicine and Clinic
基金 2015年广东省医学科研基金资助项目(A2015359)
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参考文献14

  • 1吴兆苏,姚崇华,赵冬.我国人群脑卒中发病率、死亡率的流行病学研究[J].中华流行病学杂志,2003,24(3):236-239. 被引量:722
  • 2Langhorne P, Stott DJ, Robertson L, et al. Medical com plications after stroke: a multi central study[J]. Stroke. 2000,31(6) :1223-1229. 被引量:1
  • 3Katzan IL, Cebul RD, Husak SH, et al. The effect ot pneumonia on mortality among patients hospitalized for acute stroke[J]. Neurology, 2003,60 ( 4 ) : 620- 625. 被引量:1
  • 4Hilker R,Poetter C, Findeisen N, et al. Nosocorniai pneu monia after acute stroke: implications for neurological in tensive care medicine[J]. Stroke,2003,34(10) :975 -981. 被引量:1
  • 5Bccker KL, Snider R, Nylen ES. Procalcitonin assay in systemic inflammation, infection, and sepsis :clinical utili and limitations[J]. Critical Care Medicine, 2008, 36(3) :941-952. 被引量:1
  • 6Hussein OA,El-Toukhy MA, El-Rahman HS. Neutroph CD 64 expression in inflammatory autoimmune diseases its value in distinguishing infection from disease flare[J]. Immunological Investigations, 2010,39 ( 7 ) : 699- 712. 被引量:1
  • 7贾建平.神经病学[M]6版北京:人民卫生出版社,2008:176. 被引量:395
  • 8Niderman MS, Graven DE, Bonten MJ, et al. Americna thoracic society; infectious diseases society of America. Guidelines for the management of adults with hospital a quired, ventilator-associated, and health care associatod pneumonia[J]. American Journal of Respiratory and Crit ical Care Medicine,2005,171(4) :388- 416. 被引量:1
  • 9Khaleeq G, Garcha P, Hirani A, et al. Clinical pulmonary infection score(CPIS):relationship to mortality in pa dents with ventilator associated pneumonia (VAP) [J].Chest,2006,130(4) :218-219. 被引量:1
  • 10Kwon HM, Jeong SW, Lee SH, et al. The pneumonia score:a simple grading scale for prediction of pneumonia after acute stroke[J]. Infect Control, 2006,34 (2) : 64-68. 被引量:1

二级参考文献12

  • 1李瑶宣,李燕华,王铁建,李吕力.脑卒中患者医院内获得性肺炎危险因素分析[J].中国急救医学,2006,26(1):1-4. 被引量:44
  • 2贾建平.神经病学.6版.北京:人民卫生出版社,2008:187. 被引量:25
  • 3Hilker R,Poetter C,Findeisen N,et aL Nosocomial pneumonia after acute stroke:implications for neurological intensive care medicine.Stroke,2003,34:975-981. 被引量:1
  • 4Hinchey JA,Shephard T,Furie K,et al.Formal dysphagia screening protocols prevent pneumonia Stroke,2005,36:1972-1976. 被引量:1
  • 5Maramattom BV,Weigand S,Reinalda M,et al.Pulmonary complications after intracerebral hemorrhage.Neurocrit Care,2006,5:115-119. 被引量:1
  • 6Ohwaki K,Yano E,Nagashima H,et al.Impact of infection on length of intensive care unit stay after intracerebral hemorrhage.Neurocrit Care,2008,8:271-275. 被引量:1
  • 7Hassan A,Khealani BA,Shafqat S,et al.Stroke-associated pneumonia:microbiological data and outcome.Singapore Med J,2006,47:204-207. 被引量:1
  • 8Frontera JA,Fernandez A,Claassen J,et al.Hyperglycemia after SAH:predictors,associated complications,and impact on outcome.Stroke,2006,37:199-203. 被引量:1
  • 9Marciniak C,Korutz AW,Lin E,et al.Examination of selected clinical factors and medication use as risk factors for pneumonia during stroke rehabilitation:a case-control study.Am J Phys Med Rehabil,2009,88:30-38. 被引量:1
  • 10Mtamun K,Lim J.Role of nasogastric tube in preventing aspiration pneumonia in patients with dysphagia.Singapore Med J,2005,46:627-631. 被引量:1

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二级引证文献41

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