摘要
目的探讨手术联合化疗治疗耐多药肺结核的临床疗效,评价其价值。方法将60例耐多药肺结核患者,按随机数字法分为两组,观察组30例,给予手术联合化疗,对照组30例,单用化疗,对比两组患者的临床治疗效果,同时观察不同程度耐药肺结核患者的术后痰菌转阴率、并发症发生情况。结果观察组治疗第6、12、24个月的痰菌转阴率高于对照组(P<0.05或0.01),肺部病灶影像学变化情况优于对照组(P<0.01);观察组中耐2药者的术后痰菌转阴率高于耐3药、耐3药以上者(P<0.05),且术后并发症发生率低于耐3药、耐3药以上者,比较差异有统计学意义(P<0.05)。结论对耐多药肺结核患者应用手术联合化疗的疗效确切,耐药程度越低,术后痰菌转阴率越高,并发症越少。
Objective To evaluate the clinical efficacy of surgery combined with chemotherapy in the treatment of multi drug-resistant tuberculosis（MDR-TB ） ,and to evaluate its worth.Methods 60 cases of MDR-TB patients were randomly di- vided into observation group and and control group with 30 cases in each.The observation group were given surgery combined with chemotherapy,and the control group were given chemotherapy alone.Then, clinical outcomes of the two groups were com- pared.At the same time ,sputum negative conversion rate and complications of patients with different levels of drug resistant tuberculosis after operation were observed.Results Sputum negative conversion rates on the 6~ month, the 12~ month, and the 24ts month in the observation group were significantly higher than those of the control group（P〈0.05 or 0.01 ）, and ima- ging changes of pulmonary lesions were better than that of the control group（ P〈0.01 ） .In the observation group ,postoperative sputum negative conversion rate of patients who resisted 2 kinds of drugs was significantly higher than those of patients who resisted 3 kinds or more than 3 kinds of drugs （P〈0.05）, and postoperative complication rate of the former was lower than that of the latter,so difference was statistically significant （P〈0.05）. Conclusion Surgery combined with chemotherapy has an exact effect in the treatment of multi drug-resistant tuberculosis（ MDR-TB ） ,the lower the resistance levels and the higher the postoperative sputum negative rate, the fewer complications.
出处
《右江医学》
2016年第2期168-170,共3页
Chinese Youjiang Medical Journal
