摘要
静脉注射人免疫球蛋白（IVIG）是从健康成人血浆中分离得到的抗体谱很广（107）、安全有效的免疫球蛋白浓缩制剂。自1979年四川大学华西医院廖清奎教授等将国产IVIG应用于临床以来，IVIG的国内外研究和临床应用发展很快，现已成为原发性和继发性免疫缺陷病，多种免疫性疾病，感染性（特别是病毒）疾病，血液、神经、呼吸等多个系统疾病，干细胞、器官移植，ICU等领域不可缺少的重要治疗手段。治疗剂量、疗程依据个体化治疗原则和IVIG的药代动力学特征（静脉输注后免疫球蛋白水平很快达高峰，3～4周后恢复至原血浆水平）选用。文献中常用的治疗方案：400mg／（kg·次），3～5d，或1000mg／（kg·次），2d，或2000mg／（kg·次），1d，以上方案多用于血小板减少性紫癜、川崎病等急性病患者。200～600mg／（kg·次），1d，每2—6周1次，多用于免疫缺陷病、感染等需要维持治疗者。现综述IVIG在临床上的应用。
Intravenous immunoglobulin （IVIG） is safe and effective concentration formulation which is ob- tained from the plasma of health adults. Domestic IVIG was used in clinical since 1979 by Liao Qingkui ,who are pediat- ric doctor form West China Second Hospital. Researches on clinical applications of IVIG are quickly developed at home and abroad, which now become the indispensable treatment for primary and secondary immunodeficiency diseases, auto- immune diseases, infectious disease（ especially for virus） , stem cell or organ transplantation and ICU areas. Treatment dose and course are administered accordding to individuals and pharmaeokinetie characteristics of IVIG, immunoglobu- lin rose to peak of drug concentration quickly, and recovery to the original level of plasma after 3 -4 weeks. Common therapeutic dose of IVIG recommended by the literature were 400 mg/（ kg ~ per time） ,3 -5 d, or 1 000 rag/（ kg ~ per time） ,2 d, or 2 000 rag/（ kg ~ per time）, 1 d, which were usually used for idiopathic thromboeytopenie purpura, Ka- wasaki disease patients. Treatment perscription of 200 -600 mg/（ kg ~ per time） , 1 d, and once every 2 -6 weeks are used for immunodeficiency diseases and infections. Now, the clinical application of IVIG was reviewed.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2016年第9期713-717,共5页
Chinese Journal of Applied Clinical Pediatrics
关键词
静脉注射
免疫球蛋白
临床应用
Intravenous infection
Immunoglohulin
Clinical application
