摘要
表面增强拉曼光谱(surface-enhanced Raman spectroscopy,SERS)近几年来在物理、化学乃至生物医学方面应用广泛。由于其具有较高的灵敏度、特异性,可用来检测人体血清成分的改变。血清中的各种生物分子包括蛋白质、脂类、核酸等都有各自的特征拉曼光谱,因此不同的拉曼位移、谱带强度及宽度,在分子水平上反映了人体血清中不同的细胞代谢异常。该文对SERS的研究概况以及在多种疾病血清检测中的最新研究进展进行了总结和进一步展望。
Recently surface-enhanced Raman spectroscopy（ SERS） has been widely used in physics,chemistry and bio-medical science. Due to its high sensitivity and specificity,SERS is often used to detect changes in serum components in humans. Various biomolecules in human serum,such as proteins,lipids and nucleic acids,have their own distinctive raman spectroscopy so that different raman shift,band intensity and width reflect different metabolic abnormalities of cells at the molecular level in human serum. In this paper we described the general situation of SERS and summarized the latest research progress in a variety of diseases of human serum. Prospects of developmenls are also outlined.
出处
《军事医学》
CAS
CSCD
北大核心
2016年第4期350-352,共3页
Military Medical Sciences
基金
国家自然科学基金重点资助项目(81230089)
关键词
光谱分析
拉曼
血清
早期诊断
spectrum analysis
raman
serum
early diagnosis
