摘要
目的探讨高危型人乳头瘤（HPV）病毒负荷量与宫颈病变的关系。方法选取2013年5月～2014年6月在本院妇科门诊接受高危型HPV病毒负荷量检测的3386例患者作为研究对象,其中阳性感染病例931例。进一步行阴道镜检查、宫颈活检和宫颈管搔刮术并送病理检查,按病毒负荷量分为A组（病毒负荷量1～100 pg/ml）、B组（病毒负荷量101～500 pg/ml）和C组（〉500 pg/ml）,观察各组的宫颈病变情况。结果确诊宫颈病变共446例。CINⅠ～Ⅲ组和宫颈癌组的年龄、病毒负荷量显著大于宫颈炎组,差异有统计学意义（P〈0.01）。宫颈炎构成比随着HPV-DNA病毒负荷量的增加而逐渐下降,差异有统计学意义（P〈0.01）。CINⅠ～Ⅲ构成比随着HPV-DNA病毒负荷量的增加而逐渐升高,差异有统计学意义（P〈0.01）;不同HPV病毒负荷量组的宫颈癌构成比比较,差异无统计学意义（P〉0.05）。结论病毒负荷量与宫颈病变发生关系密切,患者年龄越大,宫颈瘤样病变、癌变发生率越高。
Objective To explore the relationship between high-risk human papilloma virus（HPV） load and cervical lesions. Methods 3386 patients accepted high-risk HPV viral load detection in gynecological outpatient clinic of our hospital from May 2013 to June 2014 were selected as the research group,931 cases were in positive infection,who were detected with colposcopy,cervical biopsy and endocervical scraping,and pathological examinations further.According to viral load,all of them were divided into group A（viral load from 1 to 100 pg/ml）,group B（viral load from 101 to 500 pg/ml）,and group C（ more than 500 pg/ml）.The situation of cervical lesions was observed among each group. Results A total of 446 cases of cervical lesions were diagnosed.Age and viral load in CIN Ⅰ-Ⅲ group and cervical cancer group was larger than that in the cervicitis group,with significant difference（P〈0.01）.The composition ratio of cervicitis was gradually decreased with the increase of HPV-DNA virus load,with significant difference（P〈0.01）.The composition ratio of CIN Ⅰ- Ⅲ was gradually increased with the increase of HPV-DNA virus load,with significant difference（P〈0.01）.There was no significant difference in the composition ratio of cervical cancer with different HPV virus load group（P〉0.05）. Conclusion The viral load is closely related with cervical lesions.The older patient′s age becomes,the higher the incidences of cervical tumor-like lesion and cancerization are.
出处
《中国当代医药》
2016年第10期123-125,共3页
China Modern Medicine
关键词
高危型人乳头瘤
负荷量
年龄
宫颈病变
High-risk human papilloma virus
Load
Age
Cervical lesions
