摘要
目的探讨不同年龄性别健康体检者血清胱抑素C（CysC）水平,分析不同年龄性别与CysC水平的关系。方法选择接受健康体检的健康者648例,选择其中肾功能正常者611例,测定血清CysC和Cr浓度,按照不同年龄或不同性别分组统计分析。另外37例肾功能异常者,测定血清CysC和Cr浓度,并与相同年龄段肾功能正常者比较。结果不同年龄肾功能正常人群男女间血清CysC水平比较,差异均无统计学意义（t=2.449,P=0.092;t=0.176,P=0.872;t=2.030,P=0.135;t=2.376,P=0.098;t=1.549,P=0.219;t=1.732,P=0.182;t=1.095,P=0.353;t=1.732,P=0.182;t=2.449,P=0.092;t=2.611,P=0.080）。男性、女性及男女合并肾功能正常人群各年龄组间血清CysC水平差异均有统计学意义（F=5.662、5.615、7.253,均P〈0.05）。男性、女性及男女合并肾功能正常人群各年龄组血清CysC水平与年龄做线性相关分析,结果显示均呈现正相关性（r=0.525、0.511、0.522,均P〈0.05）。不同性别肾功能正常人群超过50岁各年龄段有血清CysC阳性人员出现,且各性别组阳性率均随年龄增加而增大（F=7.324、7.341、7.452,均P〈0.05）。肾功能正常人群CysC、Cr含量及阳性率均明显低于肾功能异常人群,差异均有统计学意义（t=31.080、15.472,χ2=17.043、34.105,均P〈0.05）。结论健康人群血清CysC水平与年龄有明显的正相关性,且随年龄增加而增大,这在50岁以上人群中尤为明显,而与性别无相关性。
Objective To investigate the serum cystatin C（ Cys C） levles in different age and sex healthphysical examination people, and to analyze the correlation between different ages, different genders and Cys C levles.Methods 648 healthy subjects checked with physical examination were selected. 611 patients with normal renalfunction were selected. The serum Cys C and Cr concentrations were determined and statistically analyzed according todifferent age or gender groups. The serum Cys C and Cr concentrations of other 37 patients with abnormal renal function were detected and compared with normal renal function people in the same ages. Results There were no significant differences in serum CysC levels between men and women in different ages and normal renal function people（ t =2. 449, P =0. 092; t = 0. 176, P = 0. 872; t = 2. 030, P = 0. 135; t = 2. 376, P = 0. 098; t = 1. 549, P = 0. 219; t =1 732, P =0. 182; t =1. 095, P =0. 353; t = 1. 732, P = 0. 182; t = 2. 449, P = 0. 092; t = 2. 611; P = 0. 080） . Therewere significant differences in serum Cys C level between men, women and combined with normal renal function（ F =5 662, 5. 615, 7. 253, all P 〈0. 05） . Taken the linear correlation analysis by age with serum Cys C level among men,women and combined with normal renal function groups, the results showed that had positive correlation（ r = 0. 525,0 511, 0. 522, all P 〈 0. 05） . Renal function of different genders in the health physical examination people over50 years of age appeared serum Cys C positive persons, and the positive rate of each gender group increased alone withthe increase of age（ F =7. 324, 7. 341, 7. 452, all P 〈0. 05） . The Cys C, Cr content and positive rate of renal functionin health physical examination people were significantly lower than abnormal renal function people（ t = 31. 080,15 472; χ 2 =17. 043, 34. 105; all P 〈0. 05） . Conclusion There is an evident positive correlation in health physicalexamination people between serum Cys C level and the
出处
《中国基层医药》
CAS
2016年第9期1405-1408,共4页
Chinese Journal of Primary Medicine and Pharmacy
