摘要
微小RNA(microRNAs,miRNA)是参与基因转录后水平调控的非编码内源性小分子RNA,参与细胞周期、细胞分化、生长、新陈代谢以及细胞寿命等多个生物过程。miR-155是目前研究较多的miRNA中的1种,在卵巢癌、宫颈癌和子宫内膜癌中miR-155表达存在明显异常,提示其可能在调控妇科肿瘤的发生和发展中扮演着重要角色。综述miR-155在宫颈癌、子宫内膜癌、卵巢癌等妇科恶性肿瘤中表达情况,及其对肿瘤的早期发现、临床诊断、治疗和预后评估的意义及在妇科恶性肿瘤中的研究现状。
MicroRNAs（miRNAs） are small endogenous non-coding RNA molecules capable of regulating gene expression in posttranscriptional level, miRNAs are involved in a variety of biological processes such as cell cycle regulation,differentiation, growth, metabolism and aging. miR-155 is one of the most studied miRNA, which is expressed in many human cancers. Recent studies have shown that the expression profiling of miR-155 shows evidently abnormal in ovarian cancer,cervical cancer and endometrial cancer which indicated that miR-155 might play an important role in regulate the occurrence and development of gynecological tumors. Here is to summarize the expression of miR-155 in ovarian cancer, cervical cancer and endometrial cancer and its significance in the early detection, clinical diagnosis, treatment and prognosis of tumour, as well as their research status in gynecologic malignant tumor.
出处
《国际妇产科学杂志》
CAS
2016年第2期128-130,共3页
Journal of International Obstetrics and Gynecology
