摘要
目的研究艾拉光动力治疗(ALA-PDT)、卡介菌多糖核酸注射液联合胸腺肽肠溶片治疗尖锐湿疣的效果。方法选取2020年2月至2022年6月郑州大学附属郑州中心医院收治的82例尖锐湿疣患者为研究对象,以随机双盲法分为联合组、对照组,各41例。对照组接受胸腺肽肠溶片联合ALA-PDT治疗,联合组在对照组基础上接受卡介菌多糖核酸注射液治疗。比较两组临床疗效、治疗前和治疗3个月后疣体数、皮损面积、免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、血清细胞因子[脂质过氧化物(Lpo)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]水平、6个月复发率。结果联合组临床总有效率高于对照组(P<0.05);治疗3个月后,联合组疣体数、皮损面积小于对照组(P<0.05);治疗3个月后与对照组相比,联合组CD3^(+)、CD4^(+)/CD8^(+)、CD4^(+)水平较高,CD8^(+)水平较低(P<0.05);治疗3个月后,联合组血清GM-CSF、TNF-α、Lpo、hs-CRP水平低于对照组(P<0.05);治疗后随访6个月,联合组复发率(2.56%)低于对照组(21.05%)(P<0.05)。结论采用ALA-PDT、卡介菌多糖核酸注射液与胸腺肽肠溶片联合治疗可促进尖锐湿疣患者免疫功能改善,抑制炎症反应,减轻临床症状,提高临床疗效,且复发风险较低。
Objective To study the effect of Ella photodynamic therapy(ALA-PDT),BCG polysaccharide and nucleic acid injection combined with thymosin enteric-coated tablet in the treatment of condyloma acuminatum.Methods A total of 82 patients with condyloma acuminatum admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from February 2020 to June 2022 were selected as the research subjects and randomly divided into a combined group and a control group,with 41 cases in each group.The control group was treated with thymosin enteric-coated tablets combined with ALA-PDT,while the combined group received bacillus calmette-guerin polysaccharide nucleic acid injection on the basis of the control group.The clinical efficacy of the two groups was compared,as well as the number of warts,lesion area,immune function indexes(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),and serum cytokine levels[lipid peroxide(Lpo),granulocyte-macrophage colony stimulating factor(GM-CSF),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]before treatment,after 3 months of treatment,and the recurrence rate at 6 months was compared between the two groups.Results The total clinical efficacy rate of the combined group was higher than that of the control group(P<0.05).After 3 months of treatment,the number of warts and lesion area in the combined group were smaller than those in the control group(P<0.05).After 3 months of treatment,compared with the control group,the levels of CD3^(+),CD4^(+)/CD8^(+),CD4^(+)in the combined group were higher,while the level of CD8^(+)was lower(P<0.05).After 3 months of treatment,the levels of serum GM-CSF,TNF-α,Lpo,hs-CRP in the combined group were lower than those in the control group(P<0.05).The recurrence rate of the combination group(2.56%)was lower than that of the control group(21.05%)at 6 months after treatment(P<0.05).Conclusion The combination of ALA-PDT,BCG polysaccharide and nucleic acid injection and thymosin enteric-coated tablets can improve the immune function,inhibit t
作者
陈琼
王萍
高亚丽
程灵云
CHEN Qiong;WANG Ping;GAO Yali;CHENG Lingyun(Department of Dermatology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2024年第9期1587-1590,共4页
Henan Medical Research
关键词
艾拉光动力治疗
卡介菌多糖核酸注射液
胸腺肽肠溶片
尖锐湿疣
疗效
Ella photodynamic therapy
BCG polysaccharide and nucleic acid injection
thymosin enteric-coated tablet
condyloma acuminatum
curative effect
