摘要
目的:研究CD138在宫颈正常黏膜组织、上皮内瘤变(CINⅠ/Ⅱ和CINⅢ)和宫颈鳞癌组织中的表达,探讨CD138在宫颈鳞癌淋巴结转移、CD68表达、微血管密度和临床分期中的临床病理学意义。方法:采用免疫组织化学方法检测CD138在120例宫颈鳞癌、106例CINⅢ、14例CINⅠ/Ⅱ、54例正常子宫黏膜组织中的表达情况。结果:CD138表达在宫颈癌组织最低,其次是正常宫颈黏膜组织、CINⅠ/Ⅱ和CINⅢ最高,其差异具有显著性意义(P<0.001)。CD138表达率在未发生淋巴结转移的宫颈癌组高于淋巴结转移组(P<0.05)。在宫颈癌早期(0期和Ⅰ期)CD138的表达率最高,在Ⅱ期表达率最低(P<0.001)。CD138表达率在宫颈癌组织中CD68呈阳性组明显低于阴性组(P<0.05)。宫颈癌微血管密度在CD138表达呈阳性组明显低于阴性组(P<0.05)。结论:CD138是宫颈鳞癌发生发展过程的抑制因素之一,尤其在淋巴结转移中作用明显,因此可作为判定宫颈鳞癌进程的参考指标。
Objective： To study the expression of CD138 in normal cervical mucosal tissue,cervical intraepithelial neoplasia（ CINⅠ/Ⅱ and CINⅢ） and cervical squamous cell carcinoma. And to investigate the clinical pathologic significance of CD138 expression with lymph node metastasis,microvascular density（ MVD）,CD68 expression and clinical stage in cervical squamous cell carcinoma. Methods： To detected the expression of CD138 in 120 cases of cervical squamous cell carcinoma,106 cases of CINⅢ,14 cases of CINⅠ / Ⅱ and 54 cases of normal cervical mucosa tissues. Results： The expression of CD138 was lowest in cervical cancer tissue,followed by normal cervical mucosal tissue,CIN I / II and CINIII,that there had significant difference（ P〈0. 001）. The expression level of CD138 was higher in without lymph node metastasis group than in lymph node metastasis group（ P〈0. 05）. In cervical cancer,the expression level of CD138 was higher in early stage（ stage 0 and Ⅰ） than in advanced stage（ Ⅱ）（ P〈0. 001）; and higher in CD68 expression negative group than in positive group（ P〈0. 05）. Furthermore,MVD was higher in CD138 expression negative group than in positive group（ P〈0. 05）. Conclusion： CD138 play an important role in the process of development of cervical squamous cell carcinoma,especially for the role of lymph node metastasis is more obvious. CD138 could be used as a indicators for determinate the process of progress in cervical squamous cell carcinoma.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2016年第4期553-555,共3页
Chinese Journal of Immunology
基金
国家自然科学基金(81160315
81460390)资助
关键词
CD138
宫颈鳞癌
免疫组织化学
CD138
Cervical squamous cell carcinoma
Immunohistochemistry
