摘要
目的:研究夫西地酸滴眼液流变学性质并建立动力黏度测定方法。方法:采用同轴圆筒式流变仪进行夫西地酸滴眼液流变学性质的研究;分析并比较了锥板式测量系统和同轴圆筒测量系统测定结果的差异。结果:夫西地酸滴眼液为屈服应力较小、触变性较大的剪切变稀型非牛顿流体。采用同轴圆筒式流变仪测得的动力黏度值为0.56 Pa·s(RSD 0.12%);采用3种不同(CP4/40、CP1/50、CP1/60)转子锥板式流变仪测得的动力黏度值分别为0.56 Pa·s(RSD 0.14%)、0.55 Pa·s(RSD 0.10%)与0.56Pa·s(RSD 0.08%)。结论:流变仪测定夫西地酸滴眼液的动力黏度方法简单、准确、重现性好,适合用于该滴眼液动力黏度的测定。
Objective： To investigate the rheological properties of fusidic acid eye drop（fucithalmic） and establish a determination method for its dynamic viscosity. Methods： The co-axial cylinder rheometer was adopted to investigate the rheological properties of fucithalmic. The results of different measurement systems including cone plate and co-axial cylinder were compared and analyzed. Results： Fucithalmic is a non-Newtonian shear-thinning fluid with low yield stress and high thixotropy. The dynamic viscosity is 0.56 Pa·s（RSD 0.12%） based on the co-axial cylinder rheometer. Besides, the dynamic viscosity were 0.56 Pa·s（RSD 0.14%）, 0.55 Pa·s（RSD0.10%）, and 0.56 Pa·s（RSD 0.08%） by using the cone plate rheometer with three different rotors including CP4/40, CP1/50 and CP1/60, respectively. Conclusion： The established method for dynamic viscosity determination of fucithalmic is convenient, accurate, suitable and with a good reproducibility for the dynamic viscosity of fucithalmic.
出处
《中国药事》
CAS
2016年第4期401-405,共5页
Chinese Pharmaceutical Affairs
关键词
夫西地酸滴眼液
流变学性质
动力黏度
fusidic acid eye drop
rheological properties
dynamic viscosity
