摘要
目的探讨吸入一氧化氮（inhalednitricoxide，iNO）治疗支气管肺发育不良的疗效及安全性。方法收集2012年1月至2013年12月在我院新生儿科收治的确诊支气管肺发育不良患儿65例，根据是否给予iNO治疗，将患儿分为iNO治疗组35例及对照组30例。动态观察iNO治疗前后两组患儿的心率、血压、给氧时间、辅助通气时间、住院时间、NO2浓度、高铁血红蛋白浓度及凝血功能的变化。结果iNO治疗组与对照组患儿的吸氧时间[（37±9）dVS．（55±7）d]，辅助通气时间[（29±7）dVS．（35±9）d]及住院时间[（45±9）dVS．（54±7）d]比较，差异均有统计学意义（P〈0．05）。治疗过程中两组患儿的心率、血压、凝血功能无明显变化；iNO治疗组和对照组患儿脑室内出血（28例vs．25例），动脉导管未闭（19例VS．17例），坏死性小肠结肠炎（9例vs．5例）的发生率差异均无统计学意义（P〉0．05）；iNO组患儿早产儿视网膜病变的发生率（21例vs．25例）差异有统计学意义（P〈0．05）。结论长期iNO可以缩短吸氧时间、辅助通气时间，对心血管和凝血功能无明显不良反应，不增加颅内出血、早产儿视网膜病变等的发生。
Objective To discuss the safety of inhaled nitric oxide （iNO） for bronchopulmonary dysplasia （BPD）. Methods We analysed 65 newborns diagnosed as BPD from January 2012 to December 2013 in Maternal and Child Health Hospital of the Guangxi Zhuang Autonomous Region. They were divided into iNO group（ n = 35 ） and control group（ n = 30 ） according to whether administering iNO or not. The heart rate,blood pressure, oxygen supply time, assisted ventilation time, hospital stay, concentration of NO2 and methemoglobin, and the changes of coagulation function were observed dynamically before and after iNO treatment. Results There were significant differences in oxygen supply time[ （ 37 ± 9 ） d vs. （ 55± 7 ） d ~, assisted ventilation timel （29±7） d vs. （35 ±9） d] ,hospital stay [ （45 ±9） d vs. （54 ±7） d] between iNO group and control group （P 〈 0. 05 ）. There were no obvious changes in heart rate, blood pressure and co- agulation function before and after iNO treatment（ P 〉 0. 05 ）. The incidences of the complications had no sig- nificant differences between the two groups （ P 〉 0. 05 ）. Conclusion Long-time iNO can shorten oxygen therapy time and assisted ventilation time,iNO therapy in BPD doesn＇t found serious adverse effect to cardio- vascular function as well as coagulation function, and doesn＇t increase the risk of intracranial hemorrhage and retinopathy of prematurity.
出处
《中国小儿急救医学》
CAS
2016年第4期244-247,共4页
Chinese Pediatric Emergency Medicine
基金
基金项目：广西壮族自治区卫生厅自筹课题（Z2012214）
广西壮族自治区卫生厅重点课题（重2012022）
关键词
一氧化氮
支气管肺发育不良
早产儿
Nitric oxide
Bronchopulmonary dysplasia
Preterm infant
