摘要
目的:研究参芪降糖颗粒对2型糖尿病模型大鼠血糖血脂的改善作用及其量效关系。方法:将90只大鼠随机分为正常组(12只,给予水)和实验组(78只),实验组大鼠以高脂饮食+ip链尿佐菌素复制2型糖尿病模型,造模成功后取60只大鼠随机分为模型组(水)、阳性对照组(罗格列酮片,0.04 mg/100 g)和参芪降糖颗粒低、中、高剂量组(0.025、0.05、0.1 g/100 g,分别记为SL、SM、SH组),ig给药,每天1次,连续30 d。测定大鼠体质量、空腹血糖(FBG)、空腹胰岛素(Fins)、空腹C肽和血清中尿素氮(BUN)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。结果:与正常组比较,模型组大鼠体质量减少,BUN、FBG、Fins、TC、TG水平升高,空腹C肽、HDL-C水平降低(P<0.05)。与模型组比较,各给药组大鼠血清中BUN、FBG、Fins、TC、TG水平降低,空腹C肽、HDL-C水平升高;阳性对照组和SM、SH组大鼠体质量增加(P<0.05)。与SL组比较,阳性对照组及SM、SH组大鼠FBG、Fins、TC、TG、LDL-C水平降低,空腹C肽水平升高;阳性对照组和SH组大鼠BUN水平降低,HDL-C水平升高(P<0.05)。与SM组比较,阳性对照组及SH组大鼠TG、LDL-C水平降低,HDL-C水平升高;SH组大鼠FBG、Fins、TC水平降低,空腹C肽水平升高(P<0.05)。结论:参芪降糖颗粒对2型糖尿病大鼠血糖血脂有一定的改善作用,并呈现一定的量效关系。
OBJECTIVE：To study the improvement effect of Shenqi jiangtang granules on blood glucose and blood lipid in type 2 diabetic model rats and its dose-effect relationship. METHODS：90 rats were randomly divided into normal group（water,12 rats）and experimental group（78 rats）. The experimental group was given high fat diet and streptozotocin intraperitoneally to induce type 2 diabetic model,and 60 model rats were randomly divided into model group（water）,positive control group（Rosiglitazone tablet,0.04 mg/100 g）,Shenqi jiangtang granule low-dose,medium-dose and high-dose groups（0.025,0.05 and 0.1 g/100 kg,SL,SM and SH groups）;they were given relevant medicine intragastrically once a day for 30 days. The body weight,fasting blood glucose（FBG）,fasting insulin（Fins）,fasting C-peptide and serum levels of blood urea nitrogen（BUN）,total cholesterol（TC）,glycerin trilaurate（TG）,LDL-C and HDL-C were determined. RESULTS：Compared with normal group,body weight,fasting C-peptide and HDL-C decreased in model group,while BUN,FBG,Fins,TC and TG increased（P〈0.05）. Compared with model group,the levels of BUN,FBG,Fins,TC and TG decreased in treatment groups while fasting C-peptide and HDL-C increased;body weight of rats increased in positive group,SM and SH groups（P〈0.05）. Compared with SL group,the levels of FBG,Fins,TC,TG and LDL-C decreased in positive group,SM and SH groups,while the level of fasting C-peptide increased;the level of BUN decreased in positive control group and SH group,while HDL-C increased（P〈0.05）. Compared with SM group,the levels of TG and LDL-C decreased in positive control group and SH group,while HDL-C level increased;the levels of FBG,Fins and TC decreased in SH group,while the level of fasting C-peptide increased（P〈0.05）. CONCLUSIONS：Shenqi jiangtang granules can improve blood glucose and lipid in type 2 diabetic model rats in a dose-dependent manner.
出处
《中国药房》
CAS
北大核心
2016年第13期1801-1803,共3页
China Pharmacy
关键词
参芪降糖颗粒
2型糖尿病
血糖
血脂
量效关系
大鼠
Shenqi jiangtang granules
Type 2 diabetes
Blood glucose
Blood lipid
Dose-effect relationship
Rats
