摘要
蛋白质精氨酸甲基转移酶（protein arginine methyltransferase,PRMTs）在蛋白质的甲基化中起着重要的作用,如参与可变剪切、转录后调节、RNA的加工、细胞增殖、细胞分化、细胞凋亡和肿瘤形成等[1]。目前,已经鉴定出11种该家族的成员（PRMT1~11）,根据其催化精氨酸甲基化方式的不同,可以将PRMTs分为3类（图1）[1-3]：
Protein arginine methyltransferases（ PRMTs） play crucial roles in the methylation of a series protein substrates. PRMT5 is a type Ⅱ methyltransferase that symmetrically methylates arginine residues of histone and nonhistone substrates,thereby regulating a variety of cellular processes through epigenetic control of target gene expression or post-translational modification of signaling molecules. Recently,accumulated evidence has suggested that PRMT5 may function as an oncogene. This review is aimed to summarize the oncogenic role of PRMT5 and its regulatory mechanisms in tumors.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2016年第4期752-758,共7页
Chinese Journal of Pathophysiology
基金
广州市科技计划(No.2014Y2-00084)
