摘要
目的探讨香砂养胃丸对慢性萎缩性胃炎患者的治疗效果。方法选择2013年10月~2014年11月来陕西省榆林市中医院治疗的慢性萎缩性胃炎患者84例,采用随机数字表法将其分成对照组和观察组,每组各42例。对照组患者采用胃复春治疗,3次/d,4片/次。观察组患者采用香砂养胃丸治疗,3次/d,8丸/次。观察两组患者中医证候积分、胃镜、病理活检情况及血清白细胞介素-8（IL-8）、IL-11和肿瘤坏死因子-α（TNF-α）水平变化。结果观察组总有效率为97.62%,高于对照组（80.95%）,差异有统计学意义（P〈0.05）;观察组患者中医证候总有效率为97.62%,高于对照组（73.81%）,差异有高度统计学意义（P〈0.01）。观察组患者中医证候积分[（8.28±3.46）分]、胃镜下征象[胃窦小弯：（18.11±3.09）分;胃角：（12.41±2.36）分]及病理积分[胃窦小弯：（10.56±1.78）分;胃角：（8.32±1.48）分]均低于对照组[（12.61±4.82）、（20.46±3.69）、（14.76±2.71）、（13.92±2.09）、（10.28±1.57）分],差异均有高度统计学意义（P〈0.01）。治疗后,两组患者血清IL-8、IL-11和TNF-α水平较治疗前均有所下降,且观察组患者IL-8[（7.52±1.52）ng/L]、IL-11[（49.16±6.24）ng/L]和TNF-α水平[（40.35±5.21）ng/L]均低于对照组[（9.30±1.61）、（58.68±6.39）、（52.48±5.65）ng/L],差异均有高度统计学意义（P〈0.01）。结论香砂养胃丸能有效提高慢性萎缩性胃炎的治疗效果,降低患者血清IL-8、IL-11和TNF-α水平。
Objective To probe into the effect of Xiangshayangwei Pill on the patients with chronic atrophic gastritis.Methods 84 cases of chronic atrophic gastritis were selected from those who had received treatment in Traditional Chinese Medicine Hospital of Yulin City from October 2013 to November 2014, and they were divided into control group and observation group using the random number table method, 42 cases in each group. Patients in the control group were treated with Weifuchun Pian, 3 times a day, 4 tablets each time. Observation group were treated with Xiangshayangwei Pill. 3 times a day, 8 pills each time. TCM syndrome points, gastroscopy, pathological biopsy changes of serum IL-8, IL-11 and TNF-alpha of patients in two groups were observed. Results Total effective rate in the observation group was 97.62%, higher than that in the control group（80.95%）, the difference was statistically significant（P〈 0.05）. The total effective rate of TCM syndromes in the observation group was 97.62%, higher than that in the control group（73.81%）, the difference was statistically significant（P 〈0.01）. In the observation group, TCM syndrome score[（8.28±3.46） scores], signs under gastroscope [lesser curvature：（18.11±3.09） scores; gastric angle：（12.41±2.36） scores],pathology score [lesser curvature：（10.56 ±1.78） scores; gastric angle：（8.32 ±1.48） scores] were lower than those in the control group [（12.61±4.82）,（20.46±3.69）,（14.76±2.71）,（13.92±2.09）,（10.28±1.57） scores], the differences were statistically significant（P〈 0.01）. After treatment, levels of serum IL-8, IL-11 and TNF-α of the two groups were slightly decreased, levels of serum IL-8, IL-11 and TNF-α in the observation group [（7.52±1.52）,（49.16±6.24）,（40.35±5.21） ng/L] were lower than those of the control group [（9.30 ±1.61）,（58.68 ±6.39）,（52.48 ±5.65） ng/L], the differences were statistically significant（P 〈0.01）. Conclusion Xiangshayangwei Pill can effe
出处
《中国医药导报》
CAS
2016年第10期96-99,共4页
China Medical Herald
