摘要
目的回顾性分析高胆红素血症新生儿尿液及母乳中人巨细胞病毒(HCMV)DNA结果,并探讨HCMV-DNA检测在新生儿高胆红素血症中的筛查意义。方法收集2014年1月至2014年12月在东莞市第八人民医院住院的461例母乳喂养的高胆红素血症新生儿作为观察组,另收集东莞市第八人民医院同期的450例健康新生儿作为对照组。采用FQ-PCR检测其母乳及新生儿HCMV-DNA水平,记录其检测结果。结果观察组尿液HCMV-DNA阳性239例,占51.8%,对照组尿液HCMVDNA阳性为89例,占19.8%,两者比较差异有统计学意义(P<0.01)。观察组母乳HCMV-DNA阳性367例,占79.6%,对照组母乳HCMV-DNA阳性137例,占30.4%,两者比较差异有统计学意义(P<0.01)。结论 HCMV母乳感染是新生儿HCMV感染的重要途径,母乳及尿液HCMV-DNA检测对高胆红素血症的诊断具有重要意义。
Objective To retrospectively analyze the result of HCMV-DNA of breast milk and urine of neonatal hyperbilirubinemia and evaluate the effect on screening neonatal hyperbilirubinemia.Methods Collected 461 cases of neonatal hyperbilirubinemia from January 2014 to December 2014 in our hospital,which fed with breast milk as observation group,at the same period collected 450 cases of healthy newborn in our hospital as control group.Tested the their level of HCMV-DNA in breast milk and urine with Fluorescent Quantitative PCR,recorded the testing results.Results 239 cases with positive HCMV-DNA urine were detected in observation group,accounting for 51.8%.There were 89 cases of positive HCMV-DNA urine in control group,which accounted for 19.8%,the comparative difference was statistically significant（P〈0.01）.There were 367 cases of positive HCMV-DNA breast milk in observation group,accounting for 79.6%.The positive HCMV-DNA breast milk were detected in 137 cases in control group,which accounted for 30.4%,the comparative difference was statistically significant（P〈0.01）.Conclusion The breast milk of HCMV infection was an important way of neonatal HCMV infection,the HCMV-DNA detection of breast milk and urine was of great significance to the diagnosis of neonatal hyperbilirubinemia.
出处
《国际检验医学杂志》
CAS
2016年第8期1037-1038,共2页
International Journal of Laboratory Medicine
基金
广东省东莞市科技计划医疗卫生类科研重点项目(2013108101016)
关键词
高胆红素血症
人巨细胞病毒
婴儿
hyperbilirubinemia
human cytomegalo virus
infants
