摘要
目的 探讨乙酰半胱氨酸联合沙美特罗替卡松治疗慢性阻塞性肺疾病的疗效分。方法 本试验采用单中心前瞻对照研究,将59例慢性阻塞性肺疾病（COPN）稳定期的患者随机分为试验组与对照组,对照组30例,给予祛痰、平喘治疗。试验组29例,采用乙酰半胱氨酸联合沙美特罗替卡松粉吸入剂治疗。两组患者均随访1～1.5年,观察两组患者肺功能、步行6 min距离/米、呼吸困难评分、诱导痰细胞计数。结果 试验组肺功能评分FEV1/L、FEV1/%,步行6 min距离/米、呼吸困难试验组比对照组病情明显好转（P1〈0.05,P2〈0.05,P3〈0.05）有统计学意义,从诱导痰细胞分类计数的变化可以看出中性粒细胞数计数、中性粒细胞占细胞总数白分比、单核细胞占细胞总数百分比试验组与对照组比较（P〈0.05）有统计学差异。结论 乙酰半胱氨酸联合沙美特罗替卡松治疗慢性阻塞性肺疾病效果显著,值得在临床推广。
Objective Observation on the efficacy of N-Acetylcysteine combined with Salmeterol in the treatment of chronic obstructive pulmonary disease. Totally 59 COPD were divided into two groups,observation group（30 cases） and control group（29 cases）. Control group used expectorant, and asthma treatment. Observation group used N-Acetylcysteine combined with Salmeterol. The two groups of patients were followed up for 1 to 1.5 years. Observation the Lung function, six-min walk distance, Modified Medical Research Council, the induced sputum cell count. Results FEVI/L, FEVt%, six-min walk distance, observation group were batter than that of the control group （P^1〈0.05, P^2〈0.05, P^3〈0.05）. Neutrophils white points than of total cells, monocyte percentage of total cells,observation group were batter than that of the control group. Conclusion The efficacy of N-Acetylcysteine combined with Salmeterol in the treatment of chronic obstructive pulmonary disease was well, is worth popularizing in clinical
出处
《中国医药指南》
2016年第10期112-113,共2页
Guide of China Medicine
