摘要
核酸适配体是一类能够高灵敏、高特异性地与靶标相结合的寡核普酸序列,包括小分子化合物、细胞膜表面受体、蛋白质、金属离子等,具有超强的结合能力、低免疫原性、高稳定性等特点,同时能与各种药物及载体结合,构建多元复合靶向给药系统,目前已用于肿瘤的靶向治疗。本文综述核酸适配体在临床诊断领域中的最新研究进展,为肿瘤疾病的靶向治疗提供新的干预方向,同时也为核酸适配体更为广阔的应用提供参考。
Aptamers is a class oligonucleotide sequence combinated with target of high sensitivity and high specificity,including small molecules,cell surface receptors,proteins,metal ions,etc.It has superior binding capacity,low immunogenicity,high stability and other characteristics,and can be combined with a variety of drugs and carriers to construct multiple composite targeted drug delivery system.At present,it has been used in cancer targeted therapy.This paper has reviewed the research progress of aptamers in clinical diagnostic field for the latest,to provide a new direction for the treatment of neoplastic diseases targeted interventions,while also to provide a reference for broader application prospects of aptamers.
出处
《中国当代医药》
2016年第9期25-27,共3页
China Modern Medicine
关键词
核酸适配体
临床诊断
研究进展
Aptamers
Clinical diagnosis
Research progress
